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10.3390/ijms17081273 http://scihub22266oqcxt.onion/10.3390/ijms17081273 C5000671!5000671!27527163     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (8): ä Nephropedia Template TP {{tp|p=27527163|t=2016. Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects |pdf=|usr=}}{{27527163}} gab.com Text Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27527163 #FOAvip Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM. Among several options, we highlight new promising therapeutic coadjuvants, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation. In the near future, experimental studies are expected to clear the intracellular pathways involving coadjuvants. The design of clinical trials may also contribute to new strategies with coadjuvants against the harmful effects of diabetic complications. Twit Text FOAVip Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27527163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27527163 #FOAvip English Wikipedia <ref>{{Cite pmid|27527163}}</ref> Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects #MMPMID27527163 Pereira TMC; Pimenta FS; Porto ML; Baldo MP; Campagnaro BP; Gava AL; Meyrelles SS; Vasquez EC Int J Mol Sci 2016[Aug]; 17 (8): ä PMID27527163show ga Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM. Among several options, we highlight new promising therapeutic coadjuvants, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation. In the near future, experimental studies are expected to clear the intracellular pathways involving coadjuvants. The design of clinical trials may also contribute to new strategies with coadjuvants against the harmful effects of diabetic complications. äCoadjuvants in the Diabetic Complications: Nutraceuticals and Drugs wi(epmc).pdf DeepDyve Pubget Overpricing