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10.1038/srep32119 http://scihub22266oqcxt.onion/10.1038/srep32119 C4999825!4999825 !27562371     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27562371 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human |pdf=|usr=}}{{27562371 }} gab.com Text Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27562371 #FOAvip The role of sphingosine 1-phosphate (S1P) in liver fibrosis or inflammation was not fully examined in human. Controversy exists which S1P receptors, S1P1 and S1P3 vs S1P2, would be importantly involved in its mechanism. To clarify these matters, 80 patients who received liver resection for hepatocellular carcinoma and 9 patients for metastatic liver tumor were enrolled. S1P metabolism was analyzed in background, non-tumorous liver tissue. mRNA levels of sphingosine kinase 1 (SK1) but not SK2 were increased in livers with fibrosis stages 3-4 compared to those with 0-2 and to normal liver. However, S1P was not increased in advanced fibrotic liver, where mRNA levels of S1P transporter spinster homolog 2 (SPNS2) but not S1P-degrading enzymes were enhanced. Furthermore, mRNA levels of S1P2 but not S1P1 or S1P3 were increased in advanced fibrotic liver. These increased mRNA levels of SK1, SPNS2 and S1P2 in fibrotic liver were correlated with ?-smooth muscle actin mRNA levels in liver, and with serum ALT levels. In conclusion, S1P may be actively generated, transported to outside the cells, and bind to its specific receptor in human liver to play a role in fibrosis or inflammation. Altered S1P metabolism in fibrotic liver may be their therapeutic target. Twit Text FOAVip Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27562371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27562371 #FOAvip English Wikipedia <ref>{{Cite pmid|27562371 }}</ref> Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human #MMPMID27562371 Sato M ; Ikeda H ; Uranbileg B ; Kurano M ; Saigusa D ; Aoki J ; Maki H ; Kudo H ; Hasegawa K ; Kokudo N ; Yatomi Y Sci Rep 2016[Aug]; 6 (ä): 32119 PMID27562371 show ga The role of sphingosine 1-phosphate (S1P) in liver fibrosis or inflammation was not fully examined in human. Controversy exists which S1P receptors, S1P1 and S1P3 vs S1P2, would be importantly involved in its mechanism. To clarify these matters, 80 patients who received liver resection for hepatocellular carcinoma and 9 patients for metastatic liver tumor were enrolled. S1P metabolism was analyzed in background, non-tumorous liver tissue. mRNA levels of sphingosine kinase 1 (SK1) but not SK2 were increased in livers with fibrosis stages 3-4 compared to those with 0-2 and to normal liver. However, S1P was not increased in advanced fibrotic liver, where mRNA levels of S1P transporter spinster homolog 2 (SPNS2) but not S1P-degrading enzymes were enhanced. Furthermore, mRNA levels of S1P2 but not S1P1 or S1P3 were increased in advanced fibrotic liver. These increased mRNA levels of SK1, SPNS2 and S1P2 in fibrotic liver were correlated with ?-smooth muscle actin mRNA levels in liver, and with serum ALT levels. In conclusion, S1P may be actively generated, transported to outside the cells, and bind to its specific receptor in human liver to play a role in fibrosis or inflammation. Altered S1P metabolism in fibrotic liver may be their therapeutic target. |*Gene Expression Regulation [MESH] |Aged [MESH] |Anion Transport Proteins/*biosynthesis [MESH] |Female [MESH] |Humans [MESH] |Liver Cirrhosis/*metabolism/pathology [MESH] |Liver/*metabolism/pathology [MESH] |Male [MESH] |Phosphotransferases (Alcohol Group Acceptor)/*biosynthesis [MESH] |RNA, Messenger/*biosynthesis [MESH] |Receptors, Lysosphingolipid/*biosynthesis [MESH]Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA(epmc).pdf DeepDyve Pubget Overpricing