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10.1002/psp4.12092 http://scihub22266oqcxt.onion/10.1002/psp4.12092 C4999603!4999603!27530374     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       CPT+Pharmacometrics+Syst+Pharmacol 2016 ; 5 (8): 402-10 Nephropedia Template TP {{tp|p=27530374|t=2016. Model?Based Assessment of Alternative Study Designs in Pediatric Trials Part II: Bayesian Approaches |pdf=|usr=}}{{27530374}} gab.com Text Model Based Assessment of Alternative Study Designs in Pediatric Trials Part II: Bayesian Approaches JO: CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27530374 #FOAvip This study presents a pharmacokinetic?pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed?sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non?hierarchical (NON?H) and a semi?hierarchical (SEMI?H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of response to treatment between the pediatric and adult populations. Study designs were evaluated in terms of: type I and II errors, sample size per arm (SS), trial duration (TD), and estimate precision. No substantial differences were observed between NON?H and SEMI?H. BSDs require, on average, smaller SS and TD compared to the BD, which, on the other hand, guarantees higher estimate precision. When large differences between children and adults are expected, BSDs can return very large SS. Bayesian approaches appear to outperform their frequentist counterparts in the design of pediatric trials even when little weight is given to prior information from adults. Twit Text FOAVip Model Based Assessment of Alternative Study Designs in Pediatric Trials Part II: Bayesian Approaches ????CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27530374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27530374 #FOAvip English Wikipedia <ref>{{Cite pmid|27530374}}</ref> Model?Based Assessment of Alternative Study Designs in Pediatric Trials Part II: Bayesian Approaches #MMPMID27530374 Smania G; Baiardi P; Ceci A; Cella M; Magni P CPT Pharmacometrics Syst Pharmacol 2016[Aug]; 5 (8): 402-10 PMID27530374show ga This study presents a pharmacokinetic?pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed?sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non?hierarchical (NON?H) and a semi?hierarchical (SEMI?H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of response to treatment between the pediatric and adult populations. Study designs were evaluated in terms of: type I and II errors, sample size per arm (SS), trial duration (TD), and estimate precision. No substantial differences were observed between NON?H and SEMI?H. BSDs require, on average, smaller SS and TD compared to the BD, which, on the other hand, guarantees higher estimate precision. When large differences between children and adults are expected, BSDs can return very large SS. Bayesian approaches appear to outperform their frequentist counterparts in the design of pediatric trials even when little weight is given to prior information from adults. äModel?Based Assessment of Alternative Study Designs in Pediatric Trial(epmc).pdf DeepDyve Pubget Overpricing