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10.1002/acn3.328 http://scihub22266oqcxt.onion/10.1002/acn3.328 C4999597!4999597!27606347     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27606347&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Clin+Transl+Neurol 2016 ; 3 (8): 655-63 Nephropedia Template TP {{tp|p=27606347|t=2016. Paraneoplastic cerebellar degeneration with anti?Yo antibodies ? a review |pdf=|usr=}}{{27606347}} gab.com Text Paraneoplastic cerebellar degeneration with anti Yo antibodies a review JO: Ann Clin Transl Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27606347 #FOAvip The ataxic syndrome associated with Anti?Yo antibody, or Purkinje cell cytoplasmic antibody type 1 (PCA1), is the most common variant of paraneoplastic cerebellar degeneration (PCD). The typical presentation involves the subacute development of pancerebellar deficits with a clinical plateau within 6 months. The vast majority of cases have been reported in women with pelvic or breast tumors. Magnetic resonance imaging of the brain is often normal in the early stages, with cerebellar atrophy seen later. The underlying mechanism is believed to be an immunological reaction to cerebellar degeneration?related protein 2 (CDR2), a protein usually found in the cerebellum that is ectopically produced by tumor cells. Although both B? and T?cell abnormalities are seen, there is debate about the relative importance of the autoantibodies and cytotoxic T lymphocytes in the neuronal loss. Cerebrospinal fluid abnormalities, primarily elevated protein, lymphocytic pleocytosis, and oligoclonal bands, are common in the early stages. The low prevalence of this condition has not allowed for large?scale randomized controlled trials. Immunotherapies, such as steroids, intravenous immune globulins, and plasma exchange, have been extensively used in managing this condition, with limited success. Although some reports indicate benefit from antitumor therapies like surgery and chemotherapy, this has not been consistently observed. The prognosis for anti?Yo PCD is almost uniformly poor, with most patients left bedridden. Further studies are required to clarify the pathophysiology and provide evidence?based treatment options. Twit Text FOAVip Paraneoplastic cerebellar degeneration with anti Yo antibodies a review ????Ann Clin Transl Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27606347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27606347 #FOAvip English Wikipedia <ref>{{Cite pmid|27606347}}</ref> Paraneoplastic cerebellar degeneration with anti?Yo antibodies ? a review #MMPMID27606347 Venkatraman A; Opal P Ann Clin Transl Neurol 2016[Aug]; 3 (8): 655-63 PMID27606347show ga The ataxic syndrome associated with Anti?Yo antibody, or Purkinje cell cytoplasmic antibody type 1 (PCA1), is the most common variant of paraneoplastic cerebellar degeneration (PCD). The typical presentation involves the subacute development of pancerebellar deficits with a clinical plateau within 6 months. The vast majority of cases have been reported in women with pelvic or breast tumors. Magnetic resonance imaging of the brain is often normal in the early stages, with cerebellar atrophy seen later. The underlying mechanism is believed to be an immunological reaction to cerebellar degeneration?related protein 2 (CDR2), a protein usually found in the cerebellum that is ectopically produced by tumor cells. Although both B? and T?cell abnormalities are seen, there is debate about the relative importance of the autoantibodies and cytotoxic T lymphocytes in the neuronal loss. Cerebrospinal fluid abnormalities, primarily elevated protein, lymphocytic pleocytosis, and oligoclonal bands, are common in the early stages. The low prevalence of this condition has not allowed for large?scale randomized controlled trials. Immunotherapies, such as steroids, intravenous immune globulins, and plasma exchange, have been extensively used in managing this condition, with limited success. Although some reports indicate benefit from antitumor therapies like surgery and chemotherapy, this has not been consistently observed. The prognosis for anti?Yo PCD is almost uniformly poor, with most patients left bedridden. Further studies are required to clarify the pathophysiology and provide evidence?based treatment options. äParaneoplastic cerebellar degeneration with anti?Yo antibodies ? a rev(epmc).pdf DeepDyve Pubget Overpricing