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10.1038/ncomms12598 http://scihub22266oqcxt.onion/10.1038/ncomms12598 C4999516!4999516 !27553854     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27553854 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 12598 Nephropedia Template TP {{tp|p=27553854 |t=2016. LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression |pdf=|usr=}}{{27553854 }} gab.com Text LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27553854 #FOAvip Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that LncSox4 is required for liver TIC self-renewal and tumour initiation. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver TICs and required for liver TIC self-renewal. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. Altogether, we find that LncSox4 is highly expressed in liver TICs and is required for their self-renewal. Twit Text FOAVip LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27553854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27553854 #FOAvip English Wikipedia <ref>{{Cite pmid|27553854 }}</ref> LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression #MMPMID27553854 Chen ZZ ; Huang L ; Wu YH ; Zhai WJ ; Zhu PP ; Gao YF Nat Commun 2016[Aug]; 7 (ä): 12598 PMID27553854 show ga Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that LncSox4 is required for liver TIC self-renewal and tumour initiation. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver TICs and required for liver TIC self-renewal. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. Altogether, we find that LncSox4 is highly expressed in liver TICs and is required for their self-renewal. |Animals [MESH] |Carcinoma, Hepatocellular/genetics/*metabolism/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Self Renewal/genetics [MESH] |Cell Transformation, Neoplastic/genetics [MESH] |Humans [MESH] |Liver Neoplasms/genetics/*metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Recurrence, Local/genetics/metabolism/pathology [MESH] |Neoplastic Stem Cells/*metabolism/*pathology [MESH] |Prognosis [MESH] |Promoter Regions, Genetic [MESH] |RNA, Long Noncoding/*genetics/*metabolism [MESH] |RNA, Neoplasm/genetics/metabolism [MESH] |SOXC Transcription Factors/*genetics/metabolism [MESH] |STAT3 Transcription Factor/*metabolism [MESH]LncSox4 promotes the self-renewal of liver tumour-initiating cells thr(epmc).pdf DeepDyve Pubget Overpricing