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10.1038/ncomms12623 http://scihub22266oqcxt.onion/10.1038/ncomms12623 C4999515!4999515!27554168     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27554168&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27554168|t=2016. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection |pdf=|usr=}}{{27554168}} gab.com Text Graft-infiltrating host dendritic cells play a key role in organ transplant rejection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27554168 #FOAvip Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to graft failure. Here we demonstrate that graft-infiltrating, recipient (host) dendritic cells (DCs) play a key role in driving the rejection of transplanted organs by activated (effector) T cells. We show that donor DCs that accompany heart or kidney grafts are rapidly replaced by recipient DCs. The DCs originate from non-classical monocytes and form stable, cognate interactions with effector T cells in the graft. Eliminating recipient DCs reduces the proliferation and survival of graft-infiltrating T cells and abrogates ongoing rejection or rejection mediated by transferred effector T cells. Therefore, host DCs that infiltrate transplanted organs sustain the alloimmune response after T-cell activation has already occurred. Targeting these cells provides a means for preventing or treating rejection. Twit Text FOAVip Graft-infiltrating host dendritic cells play a key role in organ transplant rejection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27554168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27554168 #FOAvip English Wikipedia <ref>{{Cite pmid|27554168}}</ref> Graft-infiltrating host dendritic cells play a key role in organ transplant rejection #MMPMID27554168 Zhuang Q; Liu Q; Divito SJ; Zeng Q; Yatim KM; Hughes AD; Rojas-Canales DM; Nakao A; Shufesky WJ; Williams AL; Humar R; Hoffman RA; Shlomchik WD; Oberbarnscheidt MH; Lakkis FG; Morelli AE Nat Commun 2016[]; 7 (ä): ä PMID27554168show ga Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to graft failure. Here we demonstrate that graft-infiltrating, recipient (host) dendritic cells (DCs) play a key role in driving the rejection of transplanted organs by activated (effector) T cells. We show that donor DCs that accompany heart or kidney grafts are rapidly replaced by recipient DCs. The DCs originate from non-classical monocytes and form stable, cognate interactions with effector T cells in the graft. Eliminating recipient DCs reduces the proliferation and survival of graft-infiltrating T cells and abrogates ongoing rejection or rejection mediated by transferred effector T cells. Therefore, host DCs that infiltrate transplanted organs sustain the alloimmune response after T-cell activation has already occurred. Targeting these cells provides a means for preventing or treating rejection. äGraft-infiltrating host dendritic cells play a key role in organ trans(epmc).pdf DeepDyve Pubget Overpricing