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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2016 ; 11
(8
): e0161958
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Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus
Infection: A Population-Based Analysis
#MMPMID27560377
Yeh CC
; Wang WC
; Wu CS
; Sung FC
; Su CT
; Shieh YH
; Chang SN
; Su FH
PLoS One
2016[]; 11
(8
): e0161958
PMID27560377
show ga
OBJECTIVE: The association between Sjögren's syndrome (SS) and chronic hepatitis
virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV)
infections are highly prevalent in Taiwan. We used a population-based
case-control study to evaluate the associations between SS and HBV and HCV
infections. MATERIALS AND METHODS: We identified 9,629 SS patients without other
concomitant autoimmune diseases and 38,516 sex- and age-matched controls without
SS from the Taiwan National Health Insurance claims data between 2000 and 2011.
We utilized multivariate logistic regression to estimate the odds ratios (ORs)
and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV
infections. Sex- and age-specific (<55 and ?55 years) risks of SS were evaluated.
RESULTS: The risk of SS was higher in patients with HCV than in those without
chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV
infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV
patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35;
?55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk
for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI =
2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61,
95% CI = 1.21-2.14). CONCLUSION: HCV infection was associated with SS; however,
HBV only associated with SS in men.
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