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10.1371/journal.pone.0161793 http://scihub22266oqcxt.onion/10.1371/journal.pone.0161793 C4999214!4999214 !27560627     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27560627 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (8 ): e0161793 Nephropedia Template TP {{tp|p=27560627 |t=2016. Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production |pdf=|usr=}}{{27560627 }} gab.com Text Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27560627 #FOAvip Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is not fully understood. Here, we showed that mumps virus (MuV) induced SGs depending on activation of protein kinase R (PKR). MuV infection strongly induced interferon (IFN)-?1, 2 and 3, and IFN-? through activation of IFN regulatory factor 3 (IRF3) via retinoic acid inducible gene-I (RIG-I) and the mitochondrial antiviral signaling (MAVS) pathway. MuV-induced IFNs were strongly upregulated in PKR-knockdown cells. MuV-induced SG formation was suppressed by knockdown of PKR and SG marker proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and T-cell-restricted intracellular antigen-1, and significantly increased the levels of MuV-induced IFN-?1. However, viral titer was not altered by suppression of SG formation. PKR was required for induction of SGs by MuV infection and regulated type III IFN (IFN-?1) mRNA stability. MuV-induced SGs partly suppressed type III IFN production by MuV; however, the limited suppression was not sufficient to inhibit MuV replication in cell culture. Our results provide insight into the relationship between SGs and IFN production induced by MuV infection. Twit Text FOAVip Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27560627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27560627 #FOAvip English Wikipedia <ref>{{Cite pmid|27560627 }}</ref> Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production #MMPMID27560627 Hashimoto S ; Yamamoto S ; Ogasawara N ; Sato T ; Yamamoto K ; Katoh H ; Kubota T ; Shiraishi T ; Kojima T ; Himi T ; Tsutsumi H ; Yokota S PLoS One 2016[]; 11 (8 ): e0161793 PMID27560627 show ga Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is not fully understood. Here, we showed that mumps virus (MuV) induced SGs depending on activation of protein kinase R (PKR). MuV infection strongly induced interferon (IFN)-?1, 2 and 3, and IFN-? through activation of IFN regulatory factor 3 (IRF3) via retinoic acid inducible gene-I (RIG-I) and the mitochondrial antiviral signaling (MAVS) pathway. MuV-induced IFNs were strongly upregulated in PKR-knockdown cells. MuV-induced SG formation was suppressed by knockdown of PKR and SG marker proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and T-cell-restricted intracellular antigen-1, and significantly increased the levels of MuV-induced IFN-?1. However, viral titer was not altered by suppression of SG formation. PKR was required for induction of SGs by MuV infection and regulated type III IFN (IFN-?1) mRNA stability. MuV-induced SGs partly suppressed type III IFN production by MuV; however, the limited suppression was not sufficient to inhibit MuV replication in cell culture. Our results provide insight into the relationship between SGs and IFN production induced by MuV infection. |Animals [MESH] |Blotting, Western [MESH] |Carrier Proteins/genetics [MESH] |Cell Line [MESH] |Chlorocebus aethiops [MESH] |Cytoplasmic Granules/metabolism/*virology [MESH] |DEAD Box Protein 58/metabolism [MESH] |DNA Helicases [MESH] |Gene Expression [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Interferon Regulatory Factor-3/metabolism [MESH] |Interferons/*biosynthesis/genetics [MESH] |Microscopy, Confocal [MESH] |Mitochondria/metabolism [MESH] |Mumps virus/*physiology [MESH] |Poly(A)-Binding Proteins/genetics [MESH] |Poly-ADP-Ribose Binding Proteins [MESH] |RNA Helicases [MESH] |RNA Interference [MESH] |RNA Recognition Motif Proteins [MESH] |Receptors, Immunologic [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction [MESH] |Stress, Physiological/physiology [MESH] |T-Cell Intracellular Antigen-1 [MESH] |Vero Cells [MESH]Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly(epmc).pdf DeepDyve Pubget Overpricing