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10.1371/journal.pone.0161826 http://scihub22266oqcxt.onion/10.1371/journal.pone.0161826 C4999199!4999199!27561008     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (8): ä Nephropedia Template TP {{tp|p=27561008|t=2016. Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo |pdf=|usr=}}{{27561008}} gab.com Text Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27561008 #FOAvip In relation to the recent trials of Intravenous Immunoglobulin (IVIG) in Alzheimer?s Disease (AD) it was demonstrated that different IgG preparations contain varying amounts of natural anti-amyloid ? (A?) antibodies as measured by ELISA. We therefore investigated the relevance of ELISA data for measuring low-affinity antibodies, such as anti-A?. We analysed the binding of different commercial Immunoglobulin G (IgG) preparations to A?, actin and tetanus toxoid in different binding assays to further investigate the possible cause for observed differences in binding to A? and actin between different IgG preparations. We show that the differences of commercial IgG preparations in binding to A? and actin in ELISA assays are artefactual and only evident in in vitro binding assays. In functional assays and in vivo animal studies the different IVIG preparations exhibited very similar potency. ELISA data alone are not appropriate to analyse and rank the binding capacity of low-affinity antibodies to A? or other endogenous self-antigens contained in IgG preparations. Additional analytical methods should be adopted to complement ELISA data. Twit Text FOAVip Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27561008 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27561008 #FOAvip English Wikipedia <ref>{{Cite pmid|27561008}}</ref> Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo #MMPMID27561008 Cattepoel S; Gaida A; Kropf A; Nolte MW; Bolli R; Miescher SM PLoS One 2016[]; 11 (8): ä PMID27561008show ga In relation to the recent trials of Intravenous Immunoglobulin (IVIG) in Alzheimer?s Disease (AD) it was demonstrated that different IgG preparations contain varying amounts of natural anti-amyloid ? (A?) antibodies as measured by ELISA. We therefore investigated the relevance of ELISA data for measuring low-affinity antibodies, such as anti-A?. We analysed the binding of different commercial Immunoglobulin G (IgG) preparations to A?, actin and tetanus toxoid in different binding assays to further investigate the possible cause for observed differences in binding to A? and actin between different IgG preparations. We show that the differences of commercial IgG preparations in binding to A? and actin in ELISA assays are artefactual and only evident in in vitro binding assays. In functional assays and in vivo animal studies the different IVIG preparations exhibited very similar potency. ELISA data alone are not appropriate to analyse and rank the binding capacity of low-affinity antibodies to A? or other endogenous self-antigens contained in IgG preparations. Additional analytical methods should be adopted to complement ELISA data. äEffect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens I(epmc).pdf DeepDyve Pubget Overpricing