Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602132
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncol+Lett
2016 ; 12
(3
): 2023-2027
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Rapid bone repair in a patient with lung cancer metastases to the spine using a
novel herbal medicine: A case report
#MMPMID27602132
Pu R
; Zhao Q
; Li Z
; Zhang L
; Luo X
; Zeren Y
; Yu C
; Li X
Oncol Lett
2016[Sep]; 12
(3
): 2023-2027
PMID27602132
show ga
The prognosis of lung carcinoma with metastasis to the bone, particularly to the
spine, is poor. Chemotherapy and radiotherapy are established treatments for
metastatic bone disease, but their effectiveness is unsatisfactory and bone
repair following their use is slow and difficult. Medicine prepared from herbal
extracts may be an alternative treatment option. The present study discusses the
case of a 59-year-old patient diagnosed with squamous cell lung cancer (T2N3M1)
in which first-line chemotherapy using docetaxel plus cisplatin failed. Heavy
multiple bone metastases were detected in the T9 vertebra and sixth left rib,
resulting in a high risk of pathological fracture. Eastern Cooperative Oncology
Group (ECOG) and numerical rating scale (NRS) scores of pain were 2 and 4,
respectively. A second-line treatment was chosen consisting of biological
intracontrol treatment (BICT) plus bisphosphonates administered over 40 days.
BICT is a therapy involving the use of herbal extracts (including ginseng, herba
agrimoniae, hairyvein agrimonia herb, white flower patrinia herb and arginine)
and palliative care. A partial positive response was reached following use of
this regimen, particularly with regard to bone repair. A computed tomography scan
revealed a 90% reduction in the broken area of the rib cage and T9 vertebra. The
bone repair was rapid and almost complete. In addition, growth of the primary
tumor in the right pulmonary hilar and metastasis in the mediastinal lymph nodes
were stabilized following treatment. ECOG and NRS scores were decreased to 1 and
0, respectively, leading to an improved quality of life. Based on these results,
the present study suggests that this herbal medicine-based regimen promotes bone
repair and inhibits tumor growth, with low toxicity. However, the mechanism by
which herbal medicine promotes rapid bone repair is unclear. Further studies are
required to determine whether cells in the tumor microenvironment are stimulated
to undergo re-differentiation by unidentified herbal substances.