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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(12
): e3200
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Impact of Antiphospholipid Syndrome and/or Systemic Lupus Erythematosus on the
Long-term Adverse Cardiovascular Outcomes in Patients After Percutaneous Coronary
Intervention: A Systematic Review and Meta-analysis
#MMPMID27015221
Bundhun PK
; Boodhoo KD
; Long MY
; Chen MH
Medicine (Baltimore)
2016[Mar]; 95
(12
): e3200
PMID27015221
show ga
Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are 2 rare
autoimmune disorders which commonly affect women. Several previous studies showed
APS to have been evolved from SLE. Secondary APS often coexists with SLE. One
common feature relating these 2 diseases are the antiphospholipid antibodies,
which are found in most of the patients with APS and in approximately 30% to 40%
of patients with SLE, among which, about 10% develop APS. The leading cause of
death in these patients is from cardiovascular disease due to accelerated
atherosclerosis, which often progresses more rapidly, compared with the general
population. However, the impact of APS and/or SLE on the cardiovascular outcomes
in patients undergoing percutaneous coronary intervention (PCI) is controversial.
Therefore, to solve this issue, we aim to compare the long-term (?1 year) adverse
cardiovascular outcomes after PCI, in patients with APS and/or SLE, and those
without these disorders.Medline and EMBASE databases were searched for studies
comparing the long-term adverse cardiovascular outcomes between SLE and non-SLE,
APS and non-APS, or SLE + APS and non-SLE + non-APS after PCI. We calculated odd
ratios (OR) and 95% confidence intervals (CIs) for these categorical variables,
and the pooled analyses were performed with RevMan 5.3.Seven studies consisting
of a total of 253,436 patients (568 patients in the experimental group and
252,868 patients in the control group) were included in this meta-analysis.
During a follow-up period of ?1 year, mortality and myocardial Infarction (MI)
were significantly higher in the experimental group (OR 2.02, 95% CI 1.63-2.49,
P?0.00001 and OR 1.59, 95% CI 1.23-2.05, P?=?0.0004, respectively). Major
adverse cardiac events and repeated revascularization were also significantly
higher in the SLE/APS group (OR 2.40, 95% CI 1.42-4.03, P?=?0.001 and OR 2.59,
95% CI 1.26-5.31, P?=?0.01, respectively).Antiphospholipid syndrome and SLE are
associated with significantly higher long-term (?1 year) adverse cardiovascular
outcomes after PCI. However, because of the limited number of patients and
researches done, and due to a larger percentage of heterogeneity observed among
several subgroups, this analysis may not generate a powerful result.