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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(25
): e3927
Nephropedia Template TP
gab.com Text
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Clinical manifestations, course, and outcome of patients with neutralizing
anti-interferon-? autoantibodies and disseminated nontuberculous mycobacterial
infections
#MMPMID27336882
Chi CY
; Lin CH
; Ho MW
; Ding JY
; Huang WC
; Shih HP
; Yeh CF
; Fung CP
; Sun HY
; Huang CT
; Wu TS
; Chang CY
; Liu YM
; Feng JY
; Wu WK
; Wang LS
; Tsai CH
; Ho CM
; Lin HS
; Chen HJ
; Lin PC
; Liao WC
; Chen WT
; Lo CC
; Wang SY
; Kuo CY
; Lee CH
; Ku CL
Medicine (Baltimore)
2016[Jun]; 95
(25
): e3927
PMID27336882
show ga
Neutralizing anti-interferon-? autoantibody (nAIGA)-associated immunodeficiency
is an emerging medical issue worldwide. In the present study, we describe and
discuss the clinical features and outcomes of patients with nAIGAs and
disseminated infections by nontuberculous mycobacteria (dNTM).We thoroughly
reviewed the medical records of all patients. Microorganisms and nAIGAs were
identified using previously described methods with modifications. All data were
calculated and analyzed using SPSS software.Among 46 adult patients with dNTM
infections, we identified 45 cases (97.8%) with nAIGAs. The average patient age
was 58.6 years, and there was no sex predominance. Cervical lymphadenitis (81.8%)
was the most common clinical manifestation. Endocrine disorder was the leading
comorbidity (7 cases). Malignancies were found in 4 patients, and all of the
malignancies originated from the T-cell/macrophage lineage. More than half of the
identifiable isolates were slow-growing NTMs. Twenty-eight (62.2%) and 18 (40.0%)
patients had a history of zoster and salmonellosis, respectively. A high
proportion of patients with recurrent episodes of NTM infection or a history of
zoster and dNTM infection had initial nAIGA titers ?10 dilution (P?0.05).
Twenty-seven patients (60.0%) required long-term antimycobacterial therapy and
had at least 1 episode of recurrent NTM disease. No mortality was related to dNTM
infection.In Taiwan, nAIGAs are a recently recognized mechanism of dNTM
infection. Long term of antibiotic treatment and adherence to medical advice are
necessary to improve the clinical outcome of patients with nAIGAs.