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2016 ; 12
(3
): 1753-1762
Nephropedia Template TP
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English Wikipedia
Significance of the hedgehog pathway-associated proteins Gli-1 and Gli-2 and the
epithelial-mesenchymal transition-associated proteins Twist and E-cadherin in
hepatocellular carcinoma
#MMPMID27602109
Chun HW
; Hong R
Oncol Lett
2016[Sep]; 12
(3
): 1753-1762
PMID27602109
show ga
It has been found that abnormal activation of the hedgehog (Hh) signaling pathway
is involved in the occurrence, invasion and metastasis of malignant tumors. In
addition, epithelial-mesenchymal transition (EMT) also performs an important
function in the invasion and metastasis of malignant tumors. However, the
significance of the Hh signaling pathway and EMT in hepatocellular carcinoma
(HCC) remains unknown. In the present study, the expression of Gli family zinc
finger 1 (Gli-1) and Gli family zinc finger 2 (Gli-2), which are key
transcriptional factors in the Hh signaling pathway, and Twist and E-cadherin,
which are two factors involved in EMT, was examined in 42 patients with HCC and
20 cases of non-tumorous liver (NTL) tissue by immunohistochemistry.
Clinicopathological information was collected in order to analyze the correlation
of the Hh signaling pathway with EMT. The present study aimed to examine the
difference in the expression of Gli-1, Gli-2, E-cadherin and Twist in HCC and NTL
to assess the diagnostic value of these factors in HCC. Additionally, the present
study aimed to elucidate the correlation between those proteins and other
clinicopathological parameters. Whether abnormal activation of the Hh signaling
pathway is closely associated with EMT was also evaluated. Gli-1 and Twist
expression was found to be significantly increased and E-cadherin expression was
found to be decreased in HCC in contrast to NTL (Gli-1, P=0.019; Twist, P=0.003;
E-cadherin, P<0.001). Increased Twist expression was associated with the tumor
size (P=0.043), and loss of or decreased E-cadherin expression was associated
with the histological type of HCC (P=0.021). There was an inverse association
between the expression of Twist and E-cadherin (P=0.006). These results showed
that Twist overexpression by induction of EMT changes is involved in the
occurrence and progression of HCC. However, the role of Hh signaling
pathway-associated proteins in HCC may require elucidation by additional studies
using additional materials in the future.
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