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2016 ; 12
(3
): 1383-1397
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gab.com Text
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English Wikipedia
Effect of breviscapine injection on clinical parameters in diabetic nephropathy:
A meta-analysis of randomized controlled trials
#MMPMID27588060
Liu X
; Yao L
; Sun D
; Zhu X
; Liu Q
; Xu T
; Wang L
Exp Ther Med
2016[Sep]; 12
(3
): 1383-1397
PMID27588060
show ga
Diabetic nephropathy (DN) is currently a major public health problem worldwide.
The objective of the present study was to evaluate the clinical effect of
breviscapine injections in patients with DN. A meta-analysis was performed using
the following databases to obtain published reports in any language:
PubMed/MEDLINE, Embase, China National Knowledge Infrastructure, Chinese
Evidence-Based Medicine, Wanfang Digital Periodicals, Chinese Academic Journals
Full-text Database, Chinese Biological and Medical Database, China Doctoral and
Masters Dissertations Full-text Database and the Chinese Proceedings of
Conference Full-text Database. Two assessors independently reviewed each trial. A
total of 35 randomized controlled trials, which performed studies on a total of
2,320 patients (1,188 in treatment groups and 1,132 in control groups), were
included in the present meta-analysis. Data were analyzed using Stata version
11.0 for Windows. The results from the analysis demonstrated that breviscapine
injections have greater therapeutic effects in patients with DN in comparison
with the control group, including renal protective effects (reducing urine
protein, serum creatinine and blood urea nitrogen) and adjustment for
dyslipidemia (affecting levels of cholesterol, triglycerides and high density
lipoproteins). These effects indicate that breviscapine injections are beneficial
to patients with DN. Further studies are required to determine the mechanisms
underlying the therapeutic effects of breviscapine.