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10.1016/j.bjhh.2016.04.003 http://scihub22266oqcxt.onion/10.1016/j.bjhh.2016.04.003 C4997889!4997889!27521865     free     free     free       Rev+Bras+Hematol+Hemoter 2016 ; 38 (3): 257-63 Nephropedia Template TP {{tp|p=27521865|t=2016. Primary myelofibrosis: current therapeutic options |pdf=|usr=}}{{27521865}} gab.com Text Primary myelofibrosis: current therapeutic options JO: Rev Bras Hematol Hemoter http://www.kidney.de/pget.php?&tw=1&pmid=27521865 #FOAvip Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of proinflammatory cytokines and hepatosplenomegaly frequently impair quality of life. Herein the main current treatment options for primary myelofibrosis patients are discussed, contemplating disease-modifying therapeutics in addition to palliative measures, in an individualized patient-based approach. Twit Text FOAVip Primary myelofibrosis: current therapeutic options ????Rev Bras Hematol Hemoter http://www.kidney.de/pget.php?&tw=1&pmid=27521865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27521865 #FOAvip English Wikipedia <ref>{{Cite pmid|27521865}}</ref> Primary myelofibrosis: current therapeutic options #MMPMID27521865 de Melo Campos P Rev Bras Hematol Hemoter 2016[Jul]; 38 (3): 257-63 PMID27521865show ga Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of proinflammatory cytokines and hepatosplenomegaly frequently impair quality of life. Herein the main current treatment options for primary myelofibrosis patients are discussed, contemplating disease-modifying therapeutics in addition to palliative measures, in an individualized patient-based approach. äPrimary myelofibrosis: current therapeutic options (epmc).pdf DeepDyve Pubget Overpricing