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10.1038/srep32260 http://scihub22266oqcxt.onion/10.1038/srep32260 C4997609!4997609!27558652     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27558652|t=2016. Wedelolactone enhances osteoblastogenesis by regulating Wnt/?-catenin signaling pathway but suppresses osteoclastogenesis by NF-?B/c-fos/NFATc1 pathway |pdf=|usr=}}{{27558652}} gab.com Text Wedelolactone enhances osteoblastogenesis by regulating Wnt/ -catenin signaling pathway but suppresses osteoclastogenesis by NF- B/c-fos/NFATc1 pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27558652 #FOAvip Bone homeostasis is maintained by formation and destruction of bone, which are two processes tightly coupled and controlled. Targeting both stimulation on bone formation and suppression on bone resorption becomes a promising strategy for treating osteoporosis. In this study, we examined the effect of wedelolactone, a natural product from Ecliptae herba, on osteoblastogenesis as well as osteoclastogenesis. In mouse bone marrow mesenchymal stem cells (BMSC), wedelolactone stimulated osteoblast differentiation and bone mineralization. At the molecular level, wedelolactone directly inhibited GSK3? activity and enhanced the phosphorylation of GSK3?, thereafter stimulated the nuclear translocation of ?-catenin and runx2. The expression of osteoblastogenesis-related marker gene including osteorix, osteocalcin and runx2 increased. At the same concentration range, wedelolactone inhibited RANKL-induced preosteoclastic RAW264.7 actin-ring formation and bone resorption pits. Further, wedelolactone blocked NF-kB/p65 phosphorylation and abrogated the NFATc1 nuclear translocation. As a result, osteoclastogenesis-related marker gene expression decreased, including c-src, c-fos, and cathepsin K. In ovariectomized mice, administration of wedelolactone prevented ovariectomy-induced bone loss by enhancing osteoblast activity and inhibiting osteoclast activity. Together, these data demonstrated that wedelolactone facilitated osteoblastogenesis through Wnt/GSK3?/?-catenin signaling pathway and suppressed RANKL-induced osteoclastogenesis through NF-?B/c-fos/NFATc1 pathway. These results suggested that wedelolacone could be a novel dual functional therapeutic agent for osteoporosis. Twit Text FOAVip Wedelolactone enhances osteoblastogenesis by regulating Wnt/ -catenin signaling pathway but suppresses osteoclastogenesis by NF- B/c-fos/NFATc1 pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27558652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27558652 #FOAvip English Wikipedia <ref>{{Cite pmid|27558652}}</ref> Wedelolactone enhances osteoblastogenesis by regulating Wnt/?-catenin signaling pathway but suppresses osteoclastogenesis by NF-?B/c-fos/NFATc1 pathway #MMPMID27558652 Liu YQ; Hong ZL; Zhan LB; Chu HY; Zhang XZ; Li GH Sci Rep 2016[]; 6 (ä): ä PMID27558652show ga Bone homeostasis is maintained by formation and destruction of bone, which are two processes tightly coupled and controlled. Targeting both stimulation on bone formation and suppression on bone resorption becomes a promising strategy for treating osteoporosis. In this study, we examined the effect of wedelolactone, a natural product from Ecliptae herba, on osteoblastogenesis as well as osteoclastogenesis. In mouse bone marrow mesenchymal stem cells (BMSC), wedelolactone stimulated osteoblast differentiation and bone mineralization. At the molecular level, wedelolactone directly inhibited GSK3? activity and enhanced the phosphorylation of GSK3?, thereafter stimulated the nuclear translocation of ?-catenin and runx2. The expression of osteoblastogenesis-related marker gene including osteorix, osteocalcin and runx2 increased. At the same concentration range, wedelolactone inhibited RANKL-induced preosteoclastic RAW264.7 actin-ring formation and bone resorption pits. Further, wedelolactone blocked NF-kB/p65 phosphorylation and abrogated the NFATc1 nuclear translocation. As a result, osteoclastogenesis-related marker gene expression decreased, including c-src, c-fos, and cathepsin K. In ovariectomized mice, administration of wedelolactone prevented ovariectomy-induced bone loss by enhancing osteoblast activity and inhibiting osteoclast activity. Together, these data demonstrated that wedelolactone facilitated osteoblastogenesis through Wnt/GSK3?/?-catenin signaling pathway and suppressed RANKL-induced osteoclastogenesis through NF-?B/c-fos/NFATc1 pathway. These results suggested that wedelolacone could be a novel dual functional therapeutic agent for osteoporosis. äWedelolactone enhances osteoblastogenesis by regulating Wnt/?-catenin (epmc).pdf DeepDyve Pubget Overpricing