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10.1038/srep31771 http://scihub22266oqcxt.onion/10.1038/srep31771 C4997336!4997336 !27558173     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27558173 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 31771 Nephropedia Template TP {{tp|p=27558173 |t=2016. Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy |pdf=|usr=}}{{27558173 }} gab.com Text Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27558173 #FOAvip Glomerular hypertension is an important factor exacerbating glomerular diseases to end-stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in hypertensive and diabetic nephropathy). The precise mechanism of glomerular sclerosis caused by glomerular hypertension is unclear, due partly to the absence of suitable in vitro or in vivo models capable of mimicking and regulating the complex mechanical forces and/or organ-level disease processes. We developed a "glomerulus-on-a-chip" (GC) microfluidic device. This device reconstitutes the glomerulus with organ-level glomerular functions to create a disease model-on-a chip that mimics hypertensive nephropathy in humans. It comprises two channels lined by closely opposed layers of glomerular endothelial cells and podocytes that experience fluid flow of physiological conditions to mimic the glomerular microenvironment in vivo. Our results revealed that glomerular mechanical forces have a crucial role in cellular cytoskeletal rearrangement as well as the damage to cells and their junctions that leads to increased glomerular leakage observed in hypertensive nephropathy. Results also showed that the GC could readily and flexibly meet the demands of a renal-disease model. The GC could provide drug screening and toxicology testing, and create potential new personalized and accurate therapeutic platforms for glomerular disease. Twit Text FOAVip Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27558173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27558173 #FOAvip English Wikipedia <ref>{{Cite pmid|27558173 }}</ref> Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy #MMPMID27558173 Zhou M ; Zhang X ; Wen X ; Wu T ; Wang W ; Yang M ; Wang J ; Fang M ; Lin B ; Lin H Sci Rep 2016[Aug]; 6 (ä): 31771 PMID27558173 show ga Glomerular hypertension is an important factor exacerbating glomerular diseases to end-stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in hypertensive and diabetic nephropathy). The precise mechanism of glomerular sclerosis caused by glomerular hypertension is unclear, due partly to the absence of suitable in vitro or in vivo models capable of mimicking and regulating the complex mechanical forces and/or organ-level disease processes. We developed a "glomerulus-on-a-chip" (GC) microfluidic device. This device reconstitutes the glomerulus with organ-level glomerular functions to create a disease model-on-a chip that mimics hypertensive nephropathy in humans. It comprises two channels lined by closely opposed layers of glomerular endothelial cells and podocytes that experience fluid flow of physiological conditions to mimic the glomerular microenvironment in vivo. Our results revealed that glomerular mechanical forces have a crucial role in cellular cytoskeletal rearrangement as well as the damage to cells and their junctions that leads to increased glomerular leakage observed in hypertensive nephropathy. Results also showed that the GC could readily and flexibly meet the demands of a renal-disease model. The GC could provide drug screening and toxicology testing, and create potential new personalized and accurate therapeutic platforms for glomerular disease. |*Lab-On-A-Chip Devices [MESH] |Actins/metabolism [MESH] |Animals [MESH] |Cell Adhesion [MESH] |Coculture Techniques [MESH] |Cytoskeleton/metabolism [MESH] |Humans [MESH] |Hypertension, Renal/*physiopathology [MESH] |Hypertension/physiopathology [MESH] |Immunoglobulin G/metabolism [MESH] |In Vitro Techniques [MESH] |Kidney Diseases/*physiopathology [MESH] |Kidney Failure, Chronic/physiopathology [MESH] |Kidney Glomerulus/*physiopathology [MESH] |Kidney/physiopathology [MESH] |Nephritis/*physiopathology [MESH] |Podocytes/cytology [MESH] |Rats [MESH] |Rats, Inbred SHR [MESH]Development of a Functional Glomerulus at the Organ Level on a Chip to(epmc).pdf DeepDyve Pubget Overpricing