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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mediators+Inflamm 2016 ; 2016 (ä): ä Nephropedia Template TP
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The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is ?Inflammation? Always Inflammation? #MMPMID27597803
Kulkarni OP; Lichtnekert J; Anders HJ; Mulay SR
Mediators Inflamm 2016[]; 2016 (ä): ä PMID27597803show ga
Inflammation is a response to infections or tissue injuries. Inflammation was once defined by clinical signs, later by the presence of leukocytes, and nowadays by expression of ?proinflammatory? cytokines and chemokines. But leukocytes and cytokines often have rather anti-inflammatory, proregenerative, and homeostatic effects. Is there a need to redefine ?inflammation?? In this review, we discuss the functions of ?inflammatory? mediators/regulators of the innate immune system that determine tissue environments to fulfill the need of the tissue while regaining homeostasis after injury.