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10.1038/ncomms12603 http://scihub22266oqcxt.onion/10.1038/ncomms12603 C4996939!4996939 !27545838     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27545838 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 12603 Nephropedia Template TP {{tp|p=27545838 |t=2016. Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation |pdf=|usr=}}{{27545838 }} gab.com Text Fscn1 is required for the trafficking of TGF- family type I receptors during endoderm formation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27545838 #FOAvip Microtubules function in TGF-? signalling by facilitating the cytoplasmic trafficking of internalized receptors and the nucleocytoplasmic shuttling of Smads. However, nothing is known about whether actin filaments are required for these processes. Here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the TGF-? superfamily member Nodal. Knockdown or knockout of fscn1a leads to a reduction of Nodal signal transduction and endoderm formation in zebrafish embryos. Fscn1 specifically interacts with TGF-? family type I receptors, and its depletion disrupts the association between receptors and actin filaments and sequesters the internalized receptors into clathrin-coated vesicles. Therefore, Fscn1 acts as a molecular linker between TGF-? family type I receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation. Twit Text FOAVip Fscn1 is required for the trafficking of TGF- family type I receptors during endoderm formation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27545838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27545838 #FOAvip English Wikipedia <ref>{{Cite pmid|27545838 }}</ref> Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation #MMPMID27545838 Liu Z ; Ning G ; Xu R ; Cao Y ; Meng A ; Wang Q Nat Commun 2016[Aug]; 7 (ä): 12603 PMID27545838 show ga Microtubules function in TGF-? signalling by facilitating the cytoplasmic trafficking of internalized receptors and the nucleocytoplasmic shuttling of Smads. However, nothing is known about whether actin filaments are required for these processes. Here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the TGF-? superfamily member Nodal. Knockdown or knockout of fscn1a leads to a reduction of Nodal signal transduction and endoderm formation in zebrafish embryos. Fscn1 specifically interacts with TGF-? family type I receptors, and its depletion disrupts the association between receptors and actin filaments and sequesters the internalized receptors into clathrin-coated vesicles. Therefore, Fscn1 acts as a molecular linker between TGF-? family type I receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation. |Actin Cytoskeleton/metabolism [MESH] |Animals [MESH] |Clathrin-Coated Vesicles/metabolism [MESH] |Endoderm/*embryology/metabolism [MESH] |Endosomes/metabolism [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Gene Knockout Techniques [MESH] |Male [MESH] |Microfilament Proteins/*physiology [MESH] |Models, Animal [MESH] |Nodal Protein/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Protein Transport/physiology [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH] |Signal Transduction/*physiology [MESH] |Zebrafish Proteins/*physiology [MESH]Fscn1 is required for the trafficking of TGF-? family type I receptors(epmc).pdf DeepDyve Pubget Overpricing