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Ablating Atrial Fibrillation: A Translational Science Perspective for Clinicians #MMPMID27241354
Weiss JN; Qu Z; Shivkumar K
Heart Rhythm 2016[Sep]; 13 (9): 1868-77 PMID27241354show ga
Although considerable progress has been made in developing ablation approaches to cure AF, outcomes are still suboptimal especially for persistent and long-lasting persistent AF. In this topical review, we review the arrhythmia mechanisms, both reentrant and non-reentrant, that are potentially relevant to human AF at various stages/settings. We describe arrhythmia mapping techniques used to distinguish between the different mechanisms, with a particular focus on the detection of rotors. We discuss which arrhythmia mechanisms are likely to respond to ablation, and the challenges and prospects for improving upon current ablation strategies to achieve better outcomes.