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2016 ; 123
(3
): 551-69
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gab.com Text
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English Wikipedia
Cardiac Embryology and Molecular Mechanisms of Congenital Heart Disease: A Primer
for Anesthesiologists
#MMPMID27541719
Kloesel B
; DiNardo JA
; Body SC
Anesth Analg
2016[Sep]; 123
(3
): 551-69
PMID27541719
show ga
Congenital heart disease is diagnosed in 0.4% to 5% of live births and presents
unique challenges to the pediatric anesthesiologist. Furthermore, advances in
surgical management have led to improved survival of those patients, and many
adult anesthesiologists now frequently take care of adolescents and adults who
have previously undergone surgery to correct or palliate congenital heart
lesions. Knowledge of abnormal heart development on the molecular and genetic
level extends and improves the anesthesiologist's understanding of congenital
heart disease. In this article, we aim to review current knowledge pertaining to
genetic alterations and their cellular effects that are involved in the formation
of congenital heart defects. Given that congenital heart disease can currently
only occasionally be traced to a single genetic mutation, we highlight some of
the difficulties that researchers face when trying to identify specific steps in
the pathogenetic development of heart lesions.