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10.1213/ANE.0000000000001451

http://scihub22266oqcxt.onion/10.1213/ANE.0000000000001451
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suck abstract from ncbi


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pmid27541719
      Anesth+Analg 2016 ; 123 (3 ): 551-69
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  • Cardiac Embryology and Molecular Mechanisms of Congenital Heart Disease: A Primer for Anesthesiologists #MMPMID27541719
  • Kloesel B ; DiNardo JA ; Body SC
  • Anesth Analg 2016[Sep]; 123 (3 ): 551-69 PMID27541719 show ga
  • Congenital heart disease is diagnosed in 0.4% to 5% of live births and presents unique challenges to the pediatric anesthesiologist. Furthermore, advances in surgical management have led to improved survival of those patients, and many adult anesthesiologists now frequently take care of adolescents and adults who have previously undergone surgery to correct or palliate congenital heart lesions. Knowledge of abnormal heart development on the molecular and genetic level extends and improves the anesthesiologist's understanding of congenital heart disease. In this article, we aim to review current knowledge pertaining to genetic alterations and their cellular effects that are involved in the formation of congenital heart defects. Given that congenital heart disease can currently only occasionally be traced to a single genetic mutation, we highlight some of the difficulties that researchers face when trying to identify specific steps in the pathogenetic development of heart lesions.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Anesthesiologists/*education [MESH]
  • |Embryonic Development/*physiology [MESH]
  • |Heart Defects, Congenital/etiology/*genetics/*pathology [MESH]
  • |Heart/*embryology/*physiology [MESH]


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