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10.21053/ceo.2015.00619

http://scihub22266oqcxt.onion/10.21053/ceo.2015.00619
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C4996095!4996095!27230273
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suck abstract from ncbi


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pmid27230273      Clin+Exp+Otorhinolaryngol 2016 ; 9 (3): 192-7
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  • Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study #MMPMID27230273
  • Kumral TL; Y?ld?r?m G; Berkiten G; Saltürk Z; Ataç E; Atar Y; Uyar Y
  • Clin Exp Otorhinolaryngol 2016[Sep]; 9 (3): 192-7 PMID27230273show ga
  • Objectives.To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. Methods.A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap inventory (THI), visual analogue scale (VAS) questionnaires and audiometric results were used to determine the effectiveness of trimetazidine treatment. Results.The study group comprised 82 tinnitus subjects, 42 (51%) of whom received trimetazidine dihydrochloride and 40 (49%) who received placebo. There was no significant difference between placebo and trimetazidine groups in THI grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant improvement was observed in subjective loudness score in either group (P>0.05). Additionally there was no significant difference between groups in pre- and posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05). Conclusion.Trimetazidine dihydrochloride therapy was ineffective for relieving chronic tinnitus.
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