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2016 ; 9
(3
): 192-7
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Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A
Randomized Double-Blind Study
#MMPMID27230273
Kumral TL
; Y?ld?r?m G
; Berkiten G
; Saltürk Z
; Ataç E
; Atar Y
; Uyar Y
Clin Exp Otorhinolaryngol
2016[Sep]; 9
(3
): 192-7
PMID27230273
show ga
OBJECTIVES: To evaluate the efficacy of trimetazidine dihydrochloride as a
treatment for chronic tinnitus. METHODS: A total of 97 chronic tinnitus patients
were evaluated in this randomized, prospective, double-blind, placebo-controlled
trial. After assessing for eligibility, 82 patients were randomly assigned into
placebo or trimetazidine groups according to the medication. The trimetazidine
group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo
group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap
inventory (THI), visual analogue scale (VAS) questionnaires and audiometric
results were used to determine the effectiveness of trimetazidine treatment.
RESULTS: The study group comprised 82 tinnitus subjects, 42 (51%) of whom
received trimetazidine dihydrochloride and 40 (49%) who received placebo. There
was no significant difference between placebo and trimetazidine groups in THI
grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant
improvement was observed in subjective loudness score in either group (P>0.05).
Additionally there was no significant difference between groups in pre- and
posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05).
CONCLUSION: Trimetazidine dihydrochloride therapy was ineffective for relieving
chronic tinnitus.