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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 F1000Res 2016 ; 5 (ä): ä Nephropedia Template TP
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Advances in understanding itching and scratching: a new era of targeted treatments #MMPMID27610225
Sanders KM; Nattkemper LA; Yosipovitch G
F1000Res 2016[]; 5 (ä): ä PMID27610225show ga
Chronic itch is a significant health burden with few effective treatments. As such, itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment. The field of itch research is dynamic, and many advances have been made so far this decade. In particular, major steps forward include the identification of new peripheral and central itch mediators and modulators, the discovery of greater roles for immune cells and glia in itch transmission, and a focus on the brain processing of itching and scratching. Finally, several new therapeutic interventions for itch have shown success in clinical trials.