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10.1186/s12859-016-1168-5 http://scihub22266oqcxt.onion/10.1186/s12859-016-1168-5 C4995621!4995621!27553370     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Bioinformatics 2016 ; 17 (1): ä Nephropedia Template TP {{tp|p=27553370|t=2016. The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment |pdf=|usr=}}{{27553370}} gab.com Text The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment JO: BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=27553370 #FOAvip Background: Research related to cancer is vast, and continues in earnest in many directions. Due to the complexity of cancer, a better understanding of tumor growth dynamics can be gleaned from a dynamic computational model. We present a comprehensive, fully executable, spatial and temporal 3D computational model of the development of a cancerous tumor together with its environment. Results: The model was created using Statecharts, which were then connected to an interactive animation front-end that we developed especially for this work, making it possible to visualize on the fly the on-going events of the system?s execution, as well as the effect of various input parameters. We were thus able to gain a better understanding of, e.g., how different amounts or thresholds of oxygen and VEGF (vascular endothelial growth factor) affect the progression of the tumor. We found that the tumor has a critical turning point, where it either dies or recovers. If minimum conditions are met at that time, it eventually develops into a full, active, growing tumor, regardless of the actual amount; otherwise it dies. Conclusions: This brings us to the conclusion that the tumor is in fact a very robust system: changing initial values of VEGF and oxygen can increase the time it takes to become fully developed, but will not necessarily completely eliminate it. Electronic supplementary material: The online version of this article (doi:10.1186/s12859-016-1168-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment ????BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=27553370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27553370 #FOAvip English Wikipedia <ref>{{Cite pmid|27553370}}</ref> The tumor as an organ: comprehensive spatial and temporal modeling of the tumor and its microenvironment #MMPMID27553370 Bloch N; Harel D BMC Bioinformatics 2016[]; 17 (1): ä PMID27553370show ga Background: Research related to cancer is vast, and continues in earnest in many directions. Due to the complexity of cancer, a better understanding of tumor growth dynamics can be gleaned from a dynamic computational model. We present a comprehensive, fully executable, spatial and temporal 3D computational model of the development of a cancerous tumor together with its environment. Results: The model was created using Statecharts, which were then connected to an interactive animation front-end that we developed especially for this work, making it possible to visualize on the fly the on-going events of the system?s execution, as well as the effect of various input parameters. We were thus able to gain a better understanding of, e.g., how different amounts or thresholds of oxygen and VEGF (vascular endothelial growth factor) affect the progression of the tumor. We found that the tumor has a critical turning point, where it either dies or recovers. If minimum conditions are met at that time, it eventually develops into a full, active, growing tumor, regardless of the actual amount; otherwise it dies. Conclusions: This brings us to the conclusion that the tumor is in fact a very robust system: changing initial values of VEGF and oxygen can increase the time it takes to become fully developed, but will not necessarily completely eliminate it. Electronic supplementary material: The online version of this article (doi:10.1186/s12859-016-1168-5) contains supplementary material, which is available to authorized users. äThe tumor as an organ: comprehensive spatial and temporal modeling of (epmc).pdf DeepDyve Pubget Overpricing