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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Dev+Cell 2016 ; 37 (4): 301-9 Nephropedia Template TP
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Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology #MMPMID27219060
Desrochers LM; Antonyak MA; Cerione RA
Dev Cell 2016[May]; 37 (4): 301-9 PMID27219060show ga
The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA transcripts, microRNAs, and even DNA to target cells, thereby altering their function. Despite the exponential growth of the EV field, a great deal remains unclear about the mechanisms that regulate exosome and MV biogenesis, as well as about how to isolate different classes of EVs and how to best take advantage of them for clinical applications.