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2016 ; 21
(9
): 1225-31
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The effect of oxytocin nasal spray on social interaction deficits observed in
young children with autism: a randomized clinical crossover trial
#MMPMID26503762
Yatawara CJ
; Einfeld SL
; Hickie IB
; Davenport TA
; Guastella AJ
Mol Psychiatry
2016[Sep]; 21
(9
): 1225-31
PMID26503762
show ga
Interventions for autism are limited. The synthetic hormone oxytocin may provide
a potential treatment to improve core social and behavioral difficulties in
autism, but its efficacy has yet to be evaluated in young children who
potentially may benefit to a greater extent. We investigated the efficacy,
tolerability and safety of oxytocin treatment in young children with autism using
a double-blind, randomized, placebo-controlled, crossover, clinical trial.
Thirty-one children with autism received 12 International Units (IU) of oxytocin
and placebo nasal spray morning and night (24?IU per day) for 5 weeks, with a
4-week washout period between each treatment. Compared with placebo, oxytocin led
to significant improvements on the primary outcome of caregiver-rated social
responsiveness. Overall, nasal spray was well tolerated, and the most common
reported adverse events were thirst, urination and constipation. This study is
the first clinical trial to support the potential of oxytocin as an early
intervention for young children with autism to help improve social interaction
deficits.
|Administration, Intranasal
[MESH]
|Autism Spectrum Disorder/drug therapy
[MESH]
|Autistic Disorder/drug therapy
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|Cross-Over Studies
[MESH]
|Double-Blind Method
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Interpersonal Relations
[MESH]
|Male
[MESH]
|Nasal Sprays
[MESH]
|Oxytocin/administration & dosage/*therapeutic use
[MESH]