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10.1016/j.exphem.2016.01.005 http://scihub22266oqcxt.onion/10.1016/j.exphem.2016.01.005 C4995062!4995062 !26921648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26921648 &cmd=llinks): Failed to open stream: HTTP request failed! 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Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome |pdf=|usr=}}{{26921648 }} gab.com Text Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome JO: Exp Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26921648 #FOAvip HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence and clinical similarities suggest a link to atypical hemolytic uremic syndrome, a disease of excessive activation of the alternative complement pathway effectively treated with a complement inhibitor, eculizumab. Therefore, we used a functional complement assay, the modified Ham test, to analyze sera of women with classic or atypical HELLP syndrome, pre-eclampsia with severe features, normal pregnancies, and healthy nonpregnant women. Sera were also evaluated using levels of the terminal product of complement activation (C5b-9). We tested the in vitro ability of eculizumab to inhibit complement activation in HELLP serum. Increased complement activation was observed in participants with classic or atypical HELLP compared with those with normal pregnancies and nonpregnant controls. Mixing HELLP serum with eculizumab-containing serum resulted in a significant decrease in cell killing compared with HELLP serum alone. We found that HELLP syndrome is associated with increased complement activation as assessed with the modified Ham test. This assay may aid in the diagnosis of HELLP syndrome and could confirm that its pathophysiology is related to that of atypical hemolytic uremic syndrome. Twit Text FOAVip Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome ????Exp Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26921648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26921648 #FOAvip English Wikipedia <ref>{{Cite pmid|26921648 }}</ref> Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome #MMPMID26921648 Vaught AJ ; Gavriilaki E ; Hueppchen N ; Blakemore K ; Yuan X ; Seifert SM ; York S ; Brodsky RA Exp Hematol 2016[May]; 44 (5 ): 390-8 PMID26921648 show ga HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence and clinical similarities suggest a link to atypical hemolytic uremic syndrome, a disease of excessive activation of the alternative complement pathway effectively treated with a complement inhibitor, eculizumab. Therefore, we used a functional complement assay, the modified Ham test, to analyze sera of women with classic or atypical HELLP syndrome, pre-eclampsia with severe features, normal pregnancies, and healthy nonpregnant women. Sera were also evaluated using levels of the terminal product of complement activation (C5b-9). We tested the in vitro ability of eculizumab to inhibit complement activation in HELLP serum. Increased complement activation was observed in participants with classic or atypical HELLP compared with those with normal pregnancies and nonpregnant controls. Mixing HELLP serum with eculizumab-containing serum resulted in a significant decrease in cell killing compared with HELLP serum alone. We found that HELLP syndrome is associated with increased complement activation as assessed with the modified Ham test. This assay may aid in the diagnosis of HELLP syndrome and could confirm that its pathophysiology is related to that of atypical hemolytic uremic syndrome. |Adult [MESH] |Analysis of Variance [MESH] |Antibodies, Monoclonal, Humanized/pharmacology [MESH] |Atypical Hemolytic Uremic Syndrome/blood/diagnosis/*physiopathology [MESH] |Case-Control Studies [MESH] |Complement Activation/drug effects/*physiology [MESH] |Complement Membrane Attack Complex/metabolism [MESH] |Complement Pathway, Alternative/drug effects/*physiology [MESH] |Female [MESH] |HELLP Syndrome/blood/diagnosis/*physiopathology [MESH] |Humans [MESH] |Pregnancy [MESH]Direct evidence of complement activation in HELLP syndrome: A link to (epmc).pdf DeepDyve Pubget Overpricing