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10.1038/ni.3509 http://scihub22266oqcxt.onion/10.1038/ni.3509 C4994870!4994870!27348412     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (9): 1037-45 Nephropedia Template TP {{tp|p=27348412|t=2016. Mitochondrial respiratory chain adaptations in macrophages contribute to antibacterial host defence |pdf=|usr=}}{{27348412}} gab.com Text Mitochondrial respiratory chain adaptations in macrophages contribute to antibacterial host defence JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip Macrophages tightly scale their core metabolism upon activation, but the precise regulation of the mitochondrial electron transport chain (ETC) and its functional implications are currently unknown. Here we show that recognition of live bacteria by macrophages transiently decreased the assembly of ETC complex I (CI) and CI-containing supercomplexes and switched the relative contribution of CI and CII to mitochondrial respiration. This was mediated by the phagosomal NADPH-oxidase and the reactive oxygen species (ROS)-dependent tyrosine-kinase Fgr. It required Toll-like receptor signalling and the NLRP3 inflammasome, which were both connected to bacterial viability-specific immune responses. Inhibition of CII during E. coli infection normalized serum levels of interleukin 1? (IL-1?) and IL-10 to levels found in mice treated with dead bacteria, and impaired control of bacteria. We thus identified ETC adaptations as an early immune-metabolic checkpoint that adjusts innate immune responses to bacterial infection. Twit Text FOAVip Mitochondrial respiratory chain adaptations in macrophages contribute to antibacterial host defence ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip English Wikipedia <ref>{{Cite pmid|27348412}}</ref> Mitochondrial respiratory chain adaptations in macrophages contribute to antibacterial host defence #MMPMID27348412 Garaude J; Acín-Pérez R; Martínez-Cano S; Enamorado M; Ugolini M; Nistal-Villán E; Hervás-Stubbs S; Pelegrín P; Sander LE; Enríquez JA; Sancho D Nat Immunol 2016[Sep]; 17 (9): 1037-45 PMID27348412show ga Macrophages tightly scale their core metabolism upon activation, but the precise regulation of the mitochondrial electron transport chain (ETC) and its functional implications are currently unknown. Here we show that recognition of live bacteria by macrophages transiently decreased the assembly of ETC complex I (CI) and CI-containing supercomplexes and switched the relative contribution of CI and CII to mitochondrial respiration. This was mediated by the phagosomal NADPH-oxidase and the reactive oxygen species (ROS)-dependent tyrosine-kinase Fgr. It required Toll-like receptor signalling and the NLRP3 inflammasome, which were both connected to bacterial viability-specific immune responses. Inhibition of CII during E. coli infection normalized serum levels of interleukin 1? (IL-1?) and IL-10 to levels found in mice treated with dead bacteria, and impaired control of bacteria. We thus identified ETC adaptations as an early immune-metabolic checkpoint that adjusts innate immune responses to bacterial infection. äMitochondrial respiratory chain adaptations in macrophages contribute (epmc).pdf DeepDyve Pubget Overpricing