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10.1038/ni.3509 http://scihub22266oqcxt.onion/10.1038/ni.3509 C4994870!4994870 !27348412     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27348412 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (9 ): 1037-1045 Nephropedia Template TP {{tp|p=27348412 |t=2016. Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense |pdf=|usr=}}{{27348412 }} gab.com Text Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip Macrophages tightly scale their core metabolism after being activated, but the precise regulation of the mitochondrial electron-transport chain (ETC) and its functional implications are currently unknown. Here we found that recognition of live bacteria by macrophages transiently decreased assembly of the ETC complex I (CI) and CI-containing super-complexes and switched the relative contributions of CI and CII to mitochondrial respiration. This was mediated by phagosomal NADPH oxidase and the reactive oxygen species (ROS)-dependent tyrosine kinase Fgr. It required Toll-like receptor signaling and the NLRP3 inflammasome, which were both connected to bacterial viability-specific immune responses. Inhibition of CII during infection with Escherichia coli normalized serum concentrations of interleukin 1? (IL-1?) and IL-10 to those in mice treated with dead bacteria and impaired control of bacteria. We have thus identified ETC adaptations as an early immunological-metabolic checkpoint that adjusts innate immune responses to bacterial infection. Twit Text FOAVip Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27348412 #FOAvip English Wikipedia <ref>{{Cite pmid|27348412 }}</ref> Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense #MMPMID27348412 Garaude J ; Acín-Pérez R ; Martínez-Cano S ; Enamorado M ; Ugolini M ; Nistal-Villán E ; Hervás-Stubbs S ; Pelegrín P ; Sander LE ; Enríquez JA ; Sancho D Nat Immunol 2016[Sep]; 17 (9 ): 1037-1045 PMID27348412 show ga Macrophages tightly scale their core metabolism after being activated, but the precise regulation of the mitochondrial electron-transport chain (ETC) and its functional implications are currently unknown. Here we found that recognition of live bacteria by macrophages transiently decreased assembly of the ETC complex I (CI) and CI-containing super-complexes and switched the relative contributions of CI and CII to mitochondrial respiration. This was mediated by phagosomal NADPH oxidase and the reactive oxygen species (ROS)-dependent tyrosine kinase Fgr. It required Toll-like receptor signaling and the NLRP3 inflammasome, which were both connected to bacterial viability-specific immune responses. Inhibition of CII during infection with Escherichia coli normalized serum concentrations of interleukin 1? (IL-1?) and IL-10 to those in mice treated with dead bacteria and impaired control of bacteria. We have thus identified ETC adaptations as an early immunological-metabolic checkpoint that adjusts innate immune responses to bacterial infection. |Animals [MESH] |Cells, Cultured [MESH] |Electron Transport Chain Complex Proteins/*metabolism [MESH] |Energy Metabolism/genetics [MESH] |Escherichia coli Infections/*immunology [MESH] |Escherichia coli K12/*immunology [MESH] |Host-Parasite Interactions [MESH] |Immunity, Innate/genetics [MESH] |Interleukin-10/metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Macrophages/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mitochondria/*metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/genetics/metabolism [MESH] |Phagocytosis [MESH]Mitochondrial respiratory-chain adaptations in macrophages contribute (epmc).pdf DeepDyve Pubget Overpricing