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2016 ; 9
(5
): 414-23
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Eletriptan in the management of acute migraine: an update on the evidence for
efficacy, safety, and consistent response
#MMPMID27582896
Capi M
; Curto M
; Lionetto L
; de Andrés F
; Gentile G
; Negro A
; Martelletti P
Ther Adv Neurol Disord
2016[Sep]; 9
(5
): 414-23
PMID27582896
show ga
Migraine is a multifactorial, neurological and disabling disorder, also
characterized by several autonomic symptoms. Triptans, selective serotonin
5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe
headache attacks. In this paper, we review the recent data on eletriptan clinical
efficacy, safety, and tolerability, and potential clinically relevant
interactions with other drugs. Among triptans, eletriptan shows a consistent and
significant clinical efficacy and a good tolerability profile in the treatment of
migraine, especially for patients with cardiovascular risk factors without
coronary artery disease. It shows the most favorable clinical response, together
with sumatriptan injections, zolmitriptan and rizatriptan. Additionally,
eletriptan shows the most complex pharmacokinetic/dynamic profile compared with
the other triptans. It is metabolized primarily by the CYP3A4 hepatic enzyme and
therefore the concomitant administration of CYP3A4-potent inhibitors should be
carefully evaluated. A relatively low risk of serotonin syndrome is given by the
co-administration with serotoninergic drugs. No clinically relevant interaction
has been found with drugs used for migraine prophylactic treatment or other acute
drugs, with the exception of ergot derivatives that should not be co-administered
with eletriptan.