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CD163 promotes hematoma absorption and improves neurological functions in
patients with intracerebral hemorrhage
#MMPMID27630696
Xie WJ
; Yu HQ
; Zhang Y
; Liu Q
; Meng HM
Neural Regen Res
2016[Jul]; 11
(7
): 1122-7
PMID27630696
show ga
Clinical outcomes are positively associated with hematoma absorption. The
monocyte-macrophage scavenger receptor, CD163, plays an important role in the
metabolism of hemoglobin, and a soluble form of CD163 is present in plasma and
other tissue fluids; therefore, we speculated that serum CD163 affects hematoma
absorption after intracerebral hemorrhage. Patients with intracerebral hemorrhage
were divided into high- and low-level groups according to the average CD163 level
(1,977.79 ± 832.91 ng/mL). Compared with the high-level group, the low-level
group had a significantly slower hematoma absorption rate, and significantly
increased National Institutes of Health Stroke Scale scores and modified Rankin
Scale scores. These results suggest that CD163 promotes hematoma absorption and
the recovery of neurological function in patients with intracerebral hemorrhage.