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10.3389/fimmu.2016.00319 http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00319 C4994014!4994014!27602031     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27602031|t=2016. The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation |pdf=|usr=}}{{27602031}} gab.com Text The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27602031 #FOAvip Antibody-mediated rejection has emerged as one of the major issues limiting the success of organ transplantation. It exerts a highly negative impact on graft function and outcome, and effective treatment is lacking. The triggers for antibody development, and the mechanisms leading to graft dysfunction and failure, are incompletely understood. The production of antibodies is dependent on instructions from various immunocytes including CD4 T-helper cells that secrete interleukin (IL)-21 and interact with antigen-specific B-cells via costimulatory molecules. In this article, we discuss the role of IL-21 in the activation and differentiation of B-cells and consider the mechanisms of IL-21 and B-cell interaction. An improved understanding of the biological mechanisms involved in antibody-mediated complications after organ transplantation could lead to the development of novel therapeutic strategies, which control humoral alloreactivity, potentially preventing and treating graft-threatening antibody-mediated rejection. Twit Text FOAVip The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27602031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602031 #FOAvip English Wikipedia <ref>{{Cite pmid|27602031}}</ref> The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation #MMPMID27602031 Wu Y; van Besouw NM; Shi Y; Hoogduijn MJ; Wang L; Baan CC Front Immunol 2016[]; 7 (ä): ä PMID27602031show ga Antibody-mediated rejection has emerged as one of the major issues limiting the success of organ transplantation. It exerts a highly negative impact on graft function and outcome, and effective treatment is lacking. The triggers for antibody development, and the mechanisms leading to graft dysfunction and failure, are incompletely understood. The production of antibodies is dependent on instructions from various immunocytes including CD4 T-helper cells that secrete interleukin (IL)-21 and interact with antigen-specific B-cells via costimulatory molecules. In this article, we discuss the role of IL-21 in the activation and differentiation of B-cells and consider the mechanisms of IL-21 and B-cell interaction. An improved understanding of the biological mechanisms involved in antibody-mediated complications after organ transplantation could lead to the development of novel therapeutic strategies, which control humoral alloreactivity, potentially preventing and treating graft-threatening antibody-mediated rejection. äThe Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses(epmc).pdf DeepDyve Pubget Overpricing