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2016 ; 2016
(ä): 2637010
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Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are
Associated with Advanced Liver Disease
#MMPMID27595094
Bamias G
; Gizis M
; Delladetsima I
; Laoudi E
; Siakavellas SI
; Koutsounas I
; Kaltsa G
; Vlachogiannakos J
; Vafiadis-Zouboulis I
; Daikos GL
; Papatheodoridis GV
; Ladas SD
Can J Gastroenterol Hepatol
2016[]; 2016
(ä): 2637010
PMID27595094
show ga
Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory
function and is overexpressed in neoplastic and inflammatory conditions. Serum
DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular
carcinoma (HCC) sequence have not been explored. Objective. To assess the levels
and significance of sDcR3 protein in various stages of chronic liver disease.
Methods. We compared sDcR3 levels between healthy controls and patients with
chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC.
Correlations between sDcR3 levels and various patient- and disease-related
factors were analyzed. Results. sDcR3 levels were significantly higher in
patients with CVH than in controls (P < 0.01). sDcR3 levels were elevated in DC
and HCC, being significantly higher compared not only to controls (P < 0.001 for
both) but to CVH patients as well (P < 0.001 for both). In addition, DcR3 protein
was detected in large quantities in the ascitic fluid of cirrhotics. In patients
with CVH, sDcR3 significantly correlated to fibrosis severity, as estimated by
Ishak score (P = 0.019) or by liver stiffness measured with elastography
(Spearman r = 0.698, P < 0.001). In cirrhotic patients, significant positive
correlations were observed between sDcR3 levels and markers of severity of
hepatic impairment, including MELD score (r = 0.653, P < 0.001). Conclusions.
Circulating levels of DcR3 are elevated during chronic liver disease and
correlate with severity of liver damage. sDcR3 may serve as marker for liver
fibrosis severity and progression to end-stage liver disease.
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