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2016 ; 36
(9
): 1622-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS OF MACULAR EDEMA AND HARD EXUDATES
AND THEIR ASSOCIATION WITH LIPID SERUM LEVELS IN TYPE 2 DIABETES
#MMPMID26991647
Davoudi S
; Papavasileiou E
; Roohipoor R
; Cho H
; Kudrimoti S
; Hancock H
; Hoadley S
; Andreoli C
; Husain D
; James M
; Penman A
; Chen CJ
; Sobrin L
Retina
2016[Sep]; 36
(9
): 1622-9
PMID26991647
show ga
PURPOSE: To determine whether hyperreflective foci (HF) and macular thickness on
spectral domain ocular coherence tomography are associated with lipid levels in
patients with Type 2 diabetes. METHODS: Two hundred and thirty-eight participants
from four sites had fundus photographs and spectral domain ocular coherence
tomography images graded for hard exudates and HF, respectively. Regression
models were used to determine the association between serum lipid levels and 1)
presence of HF and hard exudates and 2) central subfield macular thickness,
central subfield macular volume, and total macular volume. RESULTS: All patients
with hard exudates on fundus photographs had corresponding HF on spectral domain
ocular coherence tomography, but 57% of patients with HF on optical coherence
tomography did not have hard exudates detected in their fundus photographs.
Presence of HF was associated with higher total cholesterol (odds ratio = 1.13,
95% confidence interval = 1.01-1.27, P = 0.03) and higher low-density lipoprotein
levels (odds ratio = 1.17, 95% confidence interval = 1.02-1.35, P = 0.02) in
models adjusting for other risk factors. The total macular volume was also
associated with higher total cholesterol (P = 0.009) and triglyceride (P = 0.02)
levels after adjusting for other risk factors. CONCLUSION: Higher total and
low-density lipoprotein cholesterol were associated with presence of HF on
spectral domain ocular coherence tomography. Total macular volume was associated
with higher total cholesterol and triglyceride levels.
|*Exudates and Transudates
[MESH]
|*Tomography, Optical Coherence
[MESH]
|Aged
[MESH]
|Black or African American/ethnology
[MESH]
|Case-Control Studies
[MESH]
|Cholesterol, HDL/*blood
[MESH]
|Cholesterol, LDL/*blood
[MESH]
|Diabetes Mellitus, Type 2/*blood/ethnology
[MESH]