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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mol+Reprod+Dev 2016 ; 83 (5): 376-86 Nephropedia Template TP
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The molecular complexity of fertilization: Introducing the concept of a fertilization synapse #MMPMID26970099
Krauchunas A; Marcello M; Singson A
Mol Reprod Dev 2016[May]; 83 (5): 376-86 PMID26970099show ga
The details of sperm-egg interactions remain a relative mystery despite many decades of research. As new molecular complexities are being discovered, we need to revise the framework in which we think about fertilization. As such, we propose that fertilization involves the formation of a synapse between the sperm and egg. A cellular synapse is a structure that mediates cell adhesion, signaling, and secretion through specialized zones of interaction and polarity. In this review, we draw parallels between the immune synapse and fertilization and argue that we should consider sperm-egg recognition, binding, and fusion in the context of a ?fertilization synapse?.