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10.1097/MIB.0000000000000818 http://scihub22266oqcxt.onion/10.1097/MIB.0000000000000818 C4992429!4992429 !27243591     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27243591 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature |pdf=|usr=}}{{27243591 }} gab.com Text Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature JO: Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=27243591 #FOAvip Inflammatory bowel disease (IBD) is an inflammatory disorder of the intestine that affects an estimated 329 per 100,000 people in the United States and is increasing in incidence within a number of cultures worldwide. Likely due to its incompletely understood pathophysiology and etiology, the standard treatments for IBD are only efficacious in subsets of patients and often do not induce lasting remission. As a result, novel therapies are needed. The success of anti-tumor necrosis factor-? treatment in a subset of patients with IBD demonstrated that therapy targeting a single cytokine could be efficacious in IBD, and clinical trials investigating the blockade of a variety of cytokines have commenced. Interleukin (IL) 27 is a relatively recently discovered type I cytokine with established roles in infectious disease, autoimmunity, and cancer in a variety of organs. IL-27 was identified as a candidate gene for IBD, and a number of studies in mouse models of IBD have demonstrated that IL-27 therapy is protective. However, in contrast to these investigations, genetic deletion of the IL-27 receptor has been shown to be protective in some mouse models of IBD. The purpose of this review is to highlight the recent literature investigating the role of IL-27 in IBD and to discuss the possible explanations for the sometimes conflicting results of these studies. Evidence supporting IL-27 therapy as a treatment for IBD will also be discussed. Twit Text FOAVip Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature ????Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=27243591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27243591 #FOAvip English Wikipedia <ref>{{Cite pmid|27243591 }}</ref> Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature #MMPMID27243591 Andrews C ; McLean MH ; Durum SK Inflamm Bowel Dis 2016[Sep]; 22 (9 ): 2255-64 PMID27243591 show ga Inflammatory bowel disease (IBD) is an inflammatory disorder of the intestine that affects an estimated 329 per 100,000 people in the United States and is increasing in incidence within a number of cultures worldwide. Likely due to its incompletely understood pathophysiology and etiology, the standard treatments for IBD are only efficacious in subsets of patients and often do not induce lasting remission. As a result, novel therapies are needed. The success of anti-tumor necrosis factor-? treatment in a subset of patients with IBD demonstrated that therapy targeting a single cytokine could be efficacious in IBD, and clinical trials investigating the blockade of a variety of cytokines have commenced. Interleukin (IL) 27 is a relatively recently discovered type I cytokine with established roles in infectious disease, autoimmunity, and cancer in a variety of organs. IL-27 was identified as a candidate gene for IBD, and a number of studies in mouse models of IBD have demonstrated that IL-27 therapy is protective. However, in contrast to these investigations, genetic deletion of the IL-27 receptor has been shown to be protective in some mouse models of IBD. The purpose of this review is to highlight the recent literature investigating the role of IL-27 in IBD and to discuss the possible explanations for the sometimes conflicting results of these studies. Evidence supporting IL-27 therapy as a treatment for IBD will also be discussed. |Animals [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Inflammatory Bowel Diseases/*drug therapy/genetics [MESH] |Interleukin-27/*genetics/*pharmacology [MESH] |Intestinal Mucosa/*metabolism/pathology [MESH]Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Cr(epmc).pdf DeepDyve Pubget Overpricing