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10.1002/hep.28622 http://scihub22266oqcxt.onion/10.1002/hep.28622 C4992423!4992423!27115285     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepatology 2016 ; 64 (3): 865-79 Nephropedia Template TP {{tp|p=27115285|t=2016. The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF-?1 biliary secretion |pdf=|usr=}}{{27115285}} gab.com Text The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF- 1 biliary secretion JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=27115285 #FOAvip The secretin/secretin receptor (SR) axis is upregulated by proliferating cholangiocytes during cholestasis. Secretin stimulates biliary proliferation by downregulation of let-7a and subsequent upregulation of the growth-promoting factor NGF. It is not know if the secretin/SR axis plays a role in subepithelial fibrosis observed during cholestasis. Our aim was to determine the role of secretin/SR axis in the activation of biliary fibrosis in animal models and human primary sclerosing cholangitis (PSC). Studies were performed in Wild-type (WT) mice with bile duct ligation (BDL), BDL SR?/? mice or Mdr2?/? mouse models of cholestatic liver injury. In selected studies, the SR antagonist (Sec 5?27) was used to block the secretin/SR axis. Biliary proliferation and fibrosis were evaluated as well as the secretion of secretin (by cholangiocytes and S cells), the expression of markers of fibrosis, TGF-?1, TGF-?1R, let-7a and downstream expression of NGF. Correlative studies were performed in human control and PSC liver tissue biopsies, serum and bile. SR antagonist reduced biliary proliferation and hepatic fibrosis in BDL WT and Mdr2?/? mice. There was decreased expression of let-7a in BDL and Mdr2?/? cholangiocytes that was associated with increased NGF expression. Inhibition of let-7a accelerated liver fibrosis due to cholestasis. There was increased expression of TGF-?1, TGF-?1R. Significantly higher expression of secretin, SR and TGF-?1 was observed in PSC patient liver samples compared to healthy controls. In addition, there was higher expression of fibrosis genes and remarkably decreased expression of let-7a and increased expression of NGF compared to the control.Conclusion: The secretin/SR axis plays a key role in regulating the biliary contribution to cholestasis-induced hepatic fibrosis. Twit Text FOAVip The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF- 1 biliary secretion ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=27115285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27115285 #FOAvip English Wikipedia <ref>{{Cite pmid|27115285}}</ref> The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF-?1 biliary secretion #MMPMID27115285 Wu N; Meng F; Invernizzi P; Bernuzzi F; Venter J; Standeford H; Onori P; Marzioni M; Alvaro D; Franchitto A; Gaudio E; Glaser S; Alpini G Hepatology 2016[Sep]; 64 (3): 865-79 PMID27115285show ga The secretin/secretin receptor (SR) axis is upregulated by proliferating cholangiocytes during cholestasis. Secretin stimulates biliary proliferation by downregulation of let-7a and subsequent upregulation of the growth-promoting factor NGF. It is not know if the secretin/SR axis plays a role in subepithelial fibrosis observed during cholestasis. Our aim was to determine the role of secretin/SR axis in the activation of biliary fibrosis in animal models and human primary sclerosing cholangitis (PSC). Studies were performed in Wild-type (WT) mice with bile duct ligation (BDL), BDL SR?/? mice or Mdr2?/? mouse models of cholestatic liver injury. In selected studies, the SR antagonist (Sec 5?27) was used to block the secretin/SR axis. Biliary proliferation and fibrosis were evaluated as well as the secretion of secretin (by cholangiocytes and S cells), the expression of markers of fibrosis, TGF-?1, TGF-?1R, let-7a and downstream expression of NGF. Correlative studies were performed in human control and PSC liver tissue biopsies, serum and bile. SR antagonist reduced biliary proliferation and hepatic fibrosis in BDL WT and Mdr2?/? mice. There was decreased expression of let-7a in BDL and Mdr2?/? cholangiocytes that was associated with increased NGF expression. Inhibition of let-7a accelerated liver fibrosis due to cholestasis. There was increased expression of TGF-?1, TGF-?1R. Significantly higher expression of secretin, SR and TGF-?1 was observed in PSC patient liver samples compared to healthy controls. In addition, there was higher expression of fibrosis genes and remarkably decreased expression of let-7a and increased expression of NGF compared to the control.Conclusion: The secretin/SR axis plays a key role in regulating the biliary contribution to cholestasis-induced hepatic fibrosis. äThe secretin/secretin receptor axis modulates liver fibrosis through c(epmc).pdf DeepDyve Pubget Overpricing