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10.1038/ncomms12470 http://scihub22266oqcxt.onion/10.1038/ncomms12470 C4992173!4992173!27539788     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27539788|t=2016. Divergent synthesis and identification of the cellular targets of deoxyelephantopins |pdf=|usr=}}{{27539788}} gab.com Text Divergent synthesis and identification of the cellular targets of deoxyelephantopins JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27539788 #FOAvip Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in ?,?-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to access analogues of deoxyelephantopin, a sesquiterpene lactone with anticancer properties. Using alkyne-tagged cellular probes and quantitative proteomics analysis, we identified several cellular targets of deoxyelephantopin. We further demonstrate that deoxyelephantopin antagonizes PPAR? activity in situ via covalent engagement of a cysteine residue in the zinc-finger motif of this nuclear receptor. Twit Text FOAVip Divergent synthesis and identification of the cellular targets of deoxyelephantopins ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27539788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27539788 #FOAvip English Wikipedia <ref>{{Cite pmid|27539788}}</ref> Divergent synthesis and identification of the cellular targets of deoxyelephantopins #MMPMID27539788 Lagoutte R; Serba C; Abegg D; Hoch DG; Adibekian A; Winssinger N Nat Commun 2016[]; 7 (ä): ä PMID27539788show ga Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in ?,?-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to access analogues of deoxyelephantopin, a sesquiterpene lactone with anticancer properties. Using alkyne-tagged cellular probes and quantitative proteomics analysis, we identified several cellular targets of deoxyelephantopin. We further demonstrate that deoxyelephantopin antagonizes PPAR? activity in situ via covalent engagement of a cysteine residue in the zinc-finger motif of this nuclear receptor. äDivergent synthesis and identification of the cellular targets of deox(epmc).pdf DeepDyve Pubget Overpricing