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10.1038/ncomms12564 http://scihub22266oqcxt.onion/10.1038/ncomms12564 C4992155!4992155!27535718     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27535718|t=2016. Mechanosensing by the ?6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |pdf=|usr=}}{{27535718}} gab.com Text Mechanosensing by the 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify ?6-integrin as a mechanosensing integrin subunit that mediates matrix stiffness-regulated myofibroblast invasion. Increasing ?6-expression, specifically the B isoform (?6B), couples ?1-integrin to mediate MMP-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion. Human idiopathic pulmonary fibrosis lung myofibroblasts express high levels of ?6-integrin in vitro and in vivo. Genetic ablation of ?6 in collagen-expressing mesenchymal cells or pharmacological blockade of matrix stiffness-regulated ?6-expression protects mice against bleomycin injury-induced experimental lung fibrosis. These findings suggest that ?6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. Targeting this mechanosensing ?6(?1)-integrin offers a novel anti-fibrotic strategy against lung fibrosis. Twit Text FOAVip Mechanosensing by the 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip English Wikipedia <ref>{{Cite pmid|27535718}}</ref> Mechanosensing by the ?6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis #MMPMID27535718 Chen H; Qu J; Huang X; Kurundkar A; Zhu L; Yang N; Venado A; Ding Q; Liu G; Antony VB; Thannickal VJ; Zhou Y Nat Commun 2016[]; 7 (ä): ä PMID27535718show ga Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify ?6-integrin as a mechanosensing integrin subunit that mediates matrix stiffness-regulated myofibroblast invasion. Increasing ?6-expression, specifically the B isoform (?6B), couples ?1-integrin to mediate MMP-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion. Human idiopathic pulmonary fibrosis lung myofibroblasts express high levels of ?6-integrin in vitro and in vivo. Genetic ablation of ?6 in collagen-expressing mesenchymal cells or pharmacological blockade of matrix stiffness-regulated ?6-expression protects mice against bleomycin injury-induced experimental lung fibrosis. These findings suggest that ?6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. Targeting this mechanosensing ?6(?1)-integrin offers a novel anti-fibrotic strategy against lung fibrosis. äMechanosensing by the ?6-integrin confers an invasive fibroblast pheno(epmc).pdf DeepDyve Pubget Overpricing