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10.1038/ncomms12564 http://scihub22266oqcxt.onion/10.1038/ncomms12564 C4992155!4992155 !27535718     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27535718 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mechanosensing by the ?6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |pdf=|usr=}}{{27535718 }} gab.com Text Mechanosensing by the 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify ?6-integrin as a mechanosensing integrin subunit that mediates matrix stiffness-regulated myofibroblast invasion. Increasing ?6-expression, specifically the B isoform (?6B), couples ?1-integrin to mediate MMP-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion. Human idiopathic pulmonary fibrosis lung myofibroblasts express high levels of ?6-integrin in vitro and in vivo. Genetic ablation of ?6 in collagen-expressing mesenchymal cells or pharmacological blockade of matrix stiffness-regulated ?6-expression protects mice against bleomycin injury-induced experimental lung fibrosis. These findings suggest that ?6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. Targeting this mechanosensing ?6(?1)-integrin offers a novel anti-fibrotic strategy against lung fibrosis. Twit Text FOAVip Mechanosensing by the 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27535718 #FOAvip English Wikipedia <ref>{{Cite pmid|27535718 }}</ref> Mechanosensing by the ?6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis #MMPMID27535718 Chen H ; Qu J ; Huang X ; Kurundkar A ; Zhu L ; Yang N ; Venado A ; Ding Q ; Liu G ; Antony VB ; Thannickal VJ ; Zhou Y Nat Commun 2016[Aug]; 7 (ä): 12564 PMID27535718 show ga Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify ?6-integrin as a mechanosensing integrin subunit that mediates matrix stiffness-regulated myofibroblast invasion. Increasing ?6-expression, specifically the B isoform (?6B), couples ?1-integrin to mediate MMP-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion. Human idiopathic pulmonary fibrosis lung myofibroblasts express high levels of ?6-integrin in vitro and in vivo. Genetic ablation of ?6 in collagen-expressing mesenchymal cells or pharmacological blockade of matrix stiffness-regulated ?6-expression protects mice against bleomycin injury-induced experimental lung fibrosis. These findings suggest that ?6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. Targeting this mechanosensing ?6(?1)-integrin offers a novel anti-fibrotic strategy against lung fibrosis. |*Mechanotransduction, Cellular/genetics [MESH] |Animals [MESH] |Basement Membrane/metabolism/pathology [MESH] |Bleomycin [MESH] |Cell Adhesion [MESH] |Extracellular Matrix/metabolism [MESH] |Fibroblasts/*pathology [MESH] |Gene Deletion [MESH] |Humans [MESH] |Integrin alpha6/*metabolism [MESH] |Lung/*metabolism/*pathology [MESH] |Mice, Inbred C57BL [MESH] |Models, Biological [MESH] |Myofibroblasts/metabolism/pathology [MESH] |Phenotype [MESH] |Proto-Oncogene Proteins c-fos/metabolism [MESH] |Pulmonary Fibrosis/genetics/*metabolism/*pathology [MESH] |Up-Regulation [MESH]Mechanosensing by the ?6-integrin confers an invasive fibroblast pheno(epmc).pdf DeepDyve Pubget Overpricing