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10.1111/cei.12802 http://scihub22266oqcxt.onion/10.1111/cei.12802 C4991517!4991517 !27083148     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27083148 &cmd=llinks): Failed to open stream: HTTP request failed! 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The regulatory role of interferon-? producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis |pdf=|usr=}}{{27083148 }} gab.com Text The regulatory role of interferon- producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27083148 #FOAvip Interstitial pneumonia (IP) is a chronic progressive interstitial lung disease associated with poor prognosis and high mortality. However, the pathogenesis of IP remains to be elucidated. The aim of this study was to clarify the role of pulmonary ??T cells in IP. In wild-type (WT) mice exposed to bleomycin, pulmonary ??T cells were expanded and produced large amounts of interferon (IFN)-? and interleukin (IL)-17A. Histological and biochemical analyses showed that bleomycin-induced IP was more severe in T cell receptor (TCR-?-deficient (TCR?(-/-) ) mice than WT mice. In TCR?(-/-) mice, pulmonary IL-17A(+) CD4(+) ? cells expanded at days 7 and 14 after bleomycin exposure. In TCR?(-/-) mice infused with ??T cells from WT mice, the number of pulmonary IL-17A(+) CD4(+) T cells was lower than in TCR?(-/-) mice. The examination of IL-17A(-/-) TCR?(-/-) mice indicated that ??T cells suppressed pulmonary fibrosis through the suppression of IL-17A(+) CD4(+) T cells. The differentiation of T helper (Th)17 cells was determined in vitro, and CD4(+) cells isolated from TCR?(-/-) mice showed normal differentiation of Th17 cells compared with WT mice. Th17 cell differentiation was suppressed in the presence of IFN-? producing ??T cells in vitro. Pulmonary fibrosis was attenuated by IFN-?-producing ??T cells through the suppression of pulmonary IL-17A(+) CD4(+) T cells. These results suggested that pulmonary ??T cells seem to play a regulatory role in the development of bleomycin-induced IP mouse model via the suppression of IL-17A production. Twit Text FOAVip The regulatory role of interferon- producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27083148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27083148 #FOAvip English Wikipedia <ref>{{Cite pmid|27083148 }}</ref> The regulatory role of interferon-? producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis #MMPMID27083148 Segawa S ; Goto D ; Iizuka A ; Kaneko S ; Yokosawa M ; Kondo Y ; Matsumoto I ; Sumida T Clin Exp Immunol 2016[Sep]; 185 (3 ): 348-60 PMID27083148 show ga Interstitial pneumonia (IP) is a chronic progressive interstitial lung disease associated with poor prognosis and high mortality. However, the pathogenesis of IP remains to be elucidated. The aim of this study was to clarify the role of pulmonary ??T cells in IP. In wild-type (WT) mice exposed to bleomycin, pulmonary ??T cells were expanded and produced large amounts of interferon (IFN)-? and interleukin (IL)-17A. Histological and biochemical analyses showed that bleomycin-induced IP was more severe in T cell receptor (TCR-?-deficient (TCR?(-/-) ) mice than WT mice. In TCR?(-/-) mice, pulmonary IL-17A(+) CD4(+) ? cells expanded at days 7 and 14 after bleomycin exposure. In TCR?(-/-) mice infused with ??T cells from WT mice, the number of pulmonary IL-17A(+) CD4(+) T cells was lower than in TCR?(-/-) mice. The examination of IL-17A(-/-) TCR?(-/-) mice indicated that ??T cells suppressed pulmonary fibrosis through the suppression of IL-17A(+) CD4(+) T cells. The differentiation of T helper (Th)17 cells was determined in vitro, and CD4(+) cells isolated from TCR?(-/-) mice showed normal differentiation of Th17 cells compared with WT mice. Th17 cell differentiation was suppressed in the presence of IFN-? producing ??T cells in vitro. Pulmonary fibrosis was attenuated by IFN-?-producing ??T cells through the suppression of pulmonary IL-17A(+) CD4(+) T cells. These results suggested that pulmonary ??T cells seem to play a regulatory role in the development of bleomycin-induced IP mouse model via the suppression of IL-17A production. |Animals [MESH] |Bleomycin/*administration & dosage [MESH] |CD4-Positive T-Lymphocytes/pathology [MESH] |Cell Differentiation [MESH] |Disease Models, Animal [MESH] |Interferon-gamma/biosynthesis [MESH] |Interleukin-17/biosynthesis/blood [MESH] |Lung Diseases, Interstitial/chemically induced/*immunology/physiopathology [MESH] |Lung/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Pulmonary Fibrosis/*immunology/physiopathology [MESH] |Receptors, Antigen, T-Cell, gamma-delta/deficiency [MESH] |T-Lymphocytes/*immunology [MESH]The regulatory role of interferon-? producing gamma delta T cells via (epmc).pdf DeepDyve Pubget Overpricing