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10.18632/oncotarget.8064 http://scihub22266oqcxt.onion/10.18632/oncotarget.8064 C4991502!4991502!26988913     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26988913&cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects |pdf=|usr=}}{{26988913}} gab.com Text Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26988913 #FOAvip Cancer development and progression is linked to tumor-associated macrophages (TAMs). Distinct TAMs subsets perform either protective or pathogenic effects in cancer. A protective role in carcinogenesis has been described for M1 macrophages, which activate antitumor mechanisms. By comparison, TAMs isolated from solid and metastatic tumors have a suppressive M2-like phenotype, which could support multiple aspects of tumor progression. Currently, it has not been clearly understood how macrophages in tumor-associated stroma could be hijacked to support tumor growth. Mesenchymal stem cells (MSCs) actively interact with components of the innate immune system and display both anti-inflammatory and pro-inflammatory effects. Here, we tested whether MSCs could favor the tumor to escape from immunologic surveillance in the presence of M1 macrophages. We found that MSCs educated by M1 condition medium (cMSCs) possessed a greatly enhanced ability in promoting tumor growth in vivo. Examination of cytokines/chemokines showed that the cMSCs acquired a regulatory profile, which expressed high levels of iNOS and MCP1. Consistent with an elevated MCP1 expression in cMSCs, the tumor-promoting effect of the cMSCs depended on MCP1 mediated macrophage recruitment to tumor sites. Furthermore, IL-6 secreted by the cMSCs could polarize infiltrated TAMs into M2-like macrophages. Therefore, when macrophages changed into M1 pro-inflammation type in tumor microenvironment, the MSCs would act as poor sensors and switchers to accelerate tumor growth. Twit Text FOAVip Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26988913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988913 #FOAvip English Wikipedia <ref>{{Cite pmid|26988913}}</ref> Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects #MMPMID26988913 Jia Xh; Feng Gw; Wang Zl; Du Y; Shen C; Hui H; Peng D; Li Zj; Kong Dl; Tian J Oncotarget 2016[Apr]; 7 (15): 20934-44 PMID26988913show ga Cancer development and progression is linked to tumor-associated macrophages (TAMs). Distinct TAMs subsets perform either protective or pathogenic effects in cancer. A protective role in carcinogenesis has been described for M1 macrophages, which activate antitumor mechanisms. By comparison, TAMs isolated from solid and metastatic tumors have a suppressive M2-like phenotype, which could support multiple aspects of tumor progression. Currently, it has not been clearly understood how macrophages in tumor-associated stroma could be hijacked to support tumor growth. Mesenchymal stem cells (MSCs) actively interact with components of the innate immune system and display both anti-inflammatory and pro-inflammatory effects. Here, we tested whether MSCs could favor the tumor to escape from immunologic surveillance in the presence of M1 macrophages. We found that MSCs educated by M1 condition medium (cMSCs) possessed a greatly enhanced ability in promoting tumor growth in vivo. Examination of cytokines/chemokines showed that the cMSCs acquired a regulatory profile, which expressed high levels of iNOS and MCP1. Consistent with an elevated MCP1 expression in cMSCs, the tumor-promoting effect of the cMSCs depended on MCP1 mediated macrophage recruitment to tumor sites. Furthermore, IL-6 secreted by the cMSCs could polarize infiltrated TAMs into M2-like macrophages. Therefore, when macrophages changed into M1 pro-inflammation type in tumor microenvironment, the MSCs would act as poor sensors and switchers to accelerate tumor growth. äActivation of mesenchymal stem cells by macrophages promotes tumor pro(epmc).pdf DeepDyve Pubget Overpricing