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10.18632/oncotarget.8346 http://scihub22266oqcxt.onion/10.18632/oncotarget.8346 C4991389!4991389 !27027357     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27027357 &cmd=llinks): Failed to open stream: HTTP request failed! 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Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis |pdf=|usr=}}{{27027357 }} gab.com Text Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27027357 #FOAvip Neutrophils play a central role in innate immunity and are rapidly recruited to sites of infection and injury. Neutrophil apoptosis is essential for the successful resolution of inflammation. Necrostatin-1 (Nec-1,methyl-thiohydantoin-tryptophan (MTH-Trp)), is a potent and specific inhibitor of necroptosis[1] (a newly identified type of cell death representing a form of programmed necrosis or regulated non apoptotic cell death) by inhibiting the receptor interacting protein 1(RIP1) kinase. Here we report that Nec-1 specifically induces caspase-dependent neutrophils apoptosis and overrides powerful anti-apoptosis signaling from survival factors such as GM-CSF and LPS. We showed that Nec-1 markedly enhanced the resolution of established neutrophil-dependent inflammation in LPS-induced acute lung injury in mice. We also provided evidence that Nec-1 promoted apoptosis by reducing the expression of the anti-apoptotic protein Mcl-1 and increasing the expression of pro-apoptotic protein Bax. Thus, Nec-1 is not only an inhibitor of necroptosis, but also a promoter of apoptosis, of neutrophils, enhancing the resolution of established inflammation by inducing apoptosis of inflammatory cells. Our results suggest that Nec-1 may have potential roles for the treatment of diseases with increased or persistent inflammatory responses. Twit Text FOAVip Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27027357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27027357 #FOAvip English Wikipedia <ref>{{Cite pmid|27027357 }}</ref> Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis #MMPMID27027357 Jie H ; He Y ; Huang X ; Zhou Q ; Han Y ; Li X ; Bai Y ; Sun E Oncotarget 2016[Apr]; 7 (15 ): 19367-81 PMID27027357 show ga Neutrophils play a central role in innate immunity and are rapidly recruited to sites of infection and injury. Neutrophil apoptosis is essential for the successful resolution of inflammation. Necrostatin-1 (Nec-1,methyl-thiohydantoin-tryptophan (MTH-Trp)), is a potent and specific inhibitor of necroptosis[1] (a newly identified type of cell death representing a form of programmed necrosis or regulated non apoptotic cell death) by inhibiting the receptor interacting protein 1(RIP1) kinase. Here we report that Nec-1 specifically induces caspase-dependent neutrophils apoptosis and overrides powerful anti-apoptosis signaling from survival factors such as GM-CSF and LPS. We showed that Nec-1 markedly enhanced the resolution of established neutrophil-dependent inflammation in LPS-induced acute lung injury in mice. We also provided evidence that Nec-1 promoted apoptosis by reducing the expression of the anti-apoptotic protein Mcl-1 and increasing the expression of pro-apoptotic protein Bax. Thus, Nec-1 is not only an inhibitor of necroptosis, but also a promoter of apoptosis, of neutrophils, enhancing the resolution of established inflammation by inducing apoptosis of inflammatory cells. Our results suggest that Nec-1 may have potential roles for the treatment of diseases with increased or persistent inflammatory responses. |Acute Lung Injury/*drug therapy/metabolism [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |Blotting, Western [MESH] |Bronchoalveolar Lavage Fluid/chemistry/cytology [MESH] |Cells, Cultured [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Imidazoles/*pharmacology [MESH] |Indoles/*pharmacology [MESH] |Inflammation Mediators/metabolism [MESH] |Inflammation/metabolism/*prevention & control [MESH] |Lung/drug effects/metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Neutrophils/*drug effects/metabolism [MESH]Necrostatin-1 enhances the resolution of inflammation by specifically (epmc).pdf DeepDyve Pubget Overpricing