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10.18632/oncotarget.8244 http://scihub22266oqcxt.onion/10.18632/oncotarget.8244 C4991384!4991384!27014914     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (15): 19299-311 Nephropedia Template TP {{tp|p=27014914|t=2016. B1a cells play a pathogenic role in the development of autoimmune arthritis |pdf=|usr=}}{{27014914}} gab.com Text B1a cells play a pathogenic role in the development of autoimmune arthritis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27014914 #FOAvip Dysregulated functions of B1 cells have been implicated in the disease progression of various autoimmune disorders, but it remains largely unclear whether B1 cells are involved in the pathogenesis of autoimmune arthritis. In this study, we found that peritoneal B1a cells underwent proliferation and migrated to the inflamed joint tissue with upregulated RANKL expression during collagen-induced arthritis (CIA) development in mice. Adoptive transfer of B1a cells exacerbated arthritic severity and joint damage while intraperitoneal depletion of B1 cells ameliorated both arthritic symptoms and joint pathology in CIA mice. In culture, RANKL-expressing B1a cells significantly promoted the expansion of osteoclasts derived from bone marrow cells, which were in accord with the in vivo findings of increased osteoclastogenesis in CIA mice transferred with B1a cells. Together, these results have demonstrated a pathogenic role of B1a cells in the development of autoimmune arthritis through RANKL-mediated osteoclastogenesis. Twit Text FOAVip B1a cells play a pathogenic role in the development of autoimmune arthritis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27014914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27014914 #FOAvip English Wikipedia <ref>{{Cite pmid|27014914}}</ref> B1a cells play a pathogenic role in the development of autoimmune arthritis #MMPMID27014914 Deng J; Wang X; Chen Q; Sun X; Xiao F; Ko KH; Zhang M; Lu L Oncotarget 2016[Apr]; 7 (15): 19299-311 PMID27014914show ga Dysregulated functions of B1 cells have been implicated in the disease progression of various autoimmune disorders, but it remains largely unclear whether B1 cells are involved in the pathogenesis of autoimmune arthritis. In this study, we found that peritoneal B1a cells underwent proliferation and migrated to the inflamed joint tissue with upregulated RANKL expression during collagen-induced arthritis (CIA) development in mice. Adoptive transfer of B1a cells exacerbated arthritic severity and joint damage while intraperitoneal depletion of B1 cells ameliorated both arthritic symptoms and joint pathology in CIA mice. In culture, RANKL-expressing B1a cells significantly promoted the expansion of osteoclasts derived from bone marrow cells, which were in accord with the in vivo findings of increased osteoclastogenesis in CIA mice transferred with B1a cells. Together, these results have demonstrated a pathogenic role of B1a cells in the development of autoimmune arthritis through RANKL-mediated osteoclastogenesis. äB1a cells play a pathogenic role in the development of autoimmune arth(epmc).pdf DeepDyve Pubget Overpricing