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10.18632/oncotarget.8278 http://scihub22266oqcxt.onion/10.18632/oncotarget.8278 C4991378!4991378!27015559     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (15): 19228-41 Nephropedia Template TP {{tp|p=27015559|t=2016. Methylomic predictors demonstrate the role of NF-?B in old-age mortality and are unrelated to the aging-associated epigenetic drift |pdf=|usr=}}{{27015559}} gab.com Text Methylomic predictors demonstrate the role of NF- B in old-age mortality and are unrelated to the aging-associated epigenetic drift JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27015559 #FOAvip Changes in the DNA methylation (DNAm) landscape have been implicated in aging and cellular senescence. To unravel the role of specific DNAm patterns in late-life survival, we performed genome-wide methylation profiling in nonagenarians (n=111) and determined the performance of the methylomic predictors and conventional risk markers in a longitudinal setting. The survival model containing only the methylomic markers was superior in terms of predictive accuracy compared with the model containing only the conventional predictors or the model containing conventional predictors combined with the methylomic markers. At the 2.55-year follow-up, we identified 19 mortality-associated (false-discovery rate <0.5) CpG sites that mapped to genes functionally clustering around the nuclear factor kappa B (NF-?B) complex. Interestingly, none of the mortality-associated CpG sites overlapped with the established aging-associated DNAm sites. Our results are in line with previous findings on the role of NF-?B in controlling animal life spans and demonstrate the role of this complex in human longevity. Twit Text FOAVip Methylomic predictors demonstrate the role of NF- B in old-age mortality and are unrelated to the aging-associated epigenetic drift ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27015559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27015559 #FOAvip English Wikipedia <ref>{{Cite pmid|27015559}}</ref> Methylomic predictors demonstrate the role of NF-?B in old-age mortality and are unrelated to the aging-associated epigenetic drift #MMPMID27015559 Jylhävä J; Kananen L; Raitanen J; Marttila S; Nevalainen T; Hervonen A; Jylhä M; Hurme M Oncotarget 2016[Apr]; 7 (15): 19228-41 PMID27015559show ga Changes in the DNA methylation (DNAm) landscape have been implicated in aging and cellular senescence. To unravel the role of specific DNAm patterns in late-life survival, we performed genome-wide methylation profiling in nonagenarians (n=111) and determined the performance of the methylomic predictors and conventional risk markers in a longitudinal setting. The survival model containing only the methylomic markers was superior in terms of predictive accuracy compared with the model containing only the conventional predictors or the model containing conventional predictors combined with the methylomic markers. At the 2.55-year follow-up, we identified 19 mortality-associated (false-discovery rate <0.5) CpG sites that mapped to genes functionally clustering around the nuclear factor kappa B (NF-?B) complex. Interestingly, none of the mortality-associated CpG sites overlapped with the established aging-associated DNAm sites. Our results are in line with previous findings on the role of NF-?B in controlling animal life spans and demonstrate the role of this complex in human longevity. äMethylomic predictors demonstrate the role of NF-?B in old-age mortali(epmc).pdf DeepDyve Pubget Overpricing