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10.1080/19491034.2016.1187354 http://scihub22266oqcxt.onion/10.1080/19491034.2016.1187354 C4991237!4991237!27187571     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleus 2016 ; 7 (3): 301-7 Nephropedia Template TP {{tp|p=27187571|t=2016. Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism |pdf=|usr=}}{{27187571}} gab.com Text Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27187571 #FOAvip Multiple layers of regulation are required to ensure appropriate patterns of gene expression for accurate cell differentiation. Interphase chromatin is non-randomly distributed within the nucleus, with highly compacted, transcriptionally silent heterochromatin enriched at the nuclear and nucleolar periphery. Whether this spatial organization serves a function in organismal physiology, rather than simply being a byproduct of chromatin metabolism, is a fundamental question. Recent work performed in C. elegans embryos characterized the molecular mechanisms that drive the perinuclear anchoring of heterochromatin. Moreover, for the first time it was shown that heterochromatin sequestration helps to restrict cell differentiation programs, while sustaining commitment to a specified fate. Here, we describe and comment on these findings, placing them in a broader context. Twit Text FOAVip Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27187571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27187571 #FOAvip English Wikipedia <ref>{{Cite pmid|27187571}}</ref> Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism #MMPMID27187571 Cabianca DS; Gasser SM Nucleus 2016[]; 7 (3): 301-7 PMID27187571show ga Multiple layers of regulation are required to ensure appropriate patterns of gene expression for accurate cell differentiation. Interphase chromatin is non-randomly distributed within the nucleus, with highly compacted, transcriptionally silent heterochromatin enriched at the nuclear and nucleolar periphery. Whether this spatial organization serves a function in organismal physiology, rather than simply being a byproduct of chromatin metabolism, is a fundamental question. Recent work performed in C. elegans embryos characterized the molecular mechanisms that drive the perinuclear anchoring of heterochromatin. Moreover, for the first time it was shown that heterochromatin sequestration helps to restrict cell differentiation programs, while sustaining commitment to a specified fate. Here, we describe and comment on these findings, placing them in a broader context. äSpatial segregation of heterochromatin: Uncovering functionality in a (epmc).pdf DeepDyve Pubget Overpricing