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10.14348/molcells.2016.0150 http://scihub22266oqcxt.onion/10.14348/molcells.2016.0150 C4990755!4990755 !27432190     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27432190 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transforming Growth Factor-?-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells |pdf=|usr=}}{{27432190 }} gab.com Text Transforming Growth Factor- -Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=27432190 #FOAvip The RNA-binding protein Rbfox3 is a well-known splicing regulator that is used as a marker for post-mitotic neurons in various vertebrate species. Although recent studies indicate a variable expression of Rbfox3 in non-neuronal tissues, including lung tissue, its cellular function in lung cancer remains largely unknown. Here, we report that the number of RBFOX3-positive cells in tumorous lung tissue is lower than that in normal lung tissue. As the transforming growth factor-? (TGF-?) signaling pathway is important in cancer progression, we investigated its role in RBFOX3 expression in A549 lung adenocarcinoma cells. TGF-?1 treatment inhibited RBFOX3 expression at the transcriptional level. Further, RBFOX3 depletion led to a change in the expression levels of a subset of proteins related to epithelial-mesenchymal transition (EMT), such as E-cadherin and Claudin-1, during TGF-?1-induced EMT. In immunofluorescence microscopic analysis, mesenchymal morphology was more prominent in RBFOX3-depleted cells than in control cells. These findings show that TGF-?-induced RBFOX3 inhibition plays an important role in EMT and propose a novel role for RBFOX3 in cancer progression. Twit Text FOAVip Transforming Growth Factor- -Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=27432190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27432190 #FOAvip English Wikipedia <ref>{{Cite pmid|27432190 }}</ref> Transforming Growth Factor-?-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells #MMPMID27432190 Kim YE ; Kim JO ; Park KS ; Won M ; Kim KE ; Kim KK Mol Cells 2016[Aug]; 39 (8 ): 625-30 PMID27432190 show ga The RNA-binding protein Rbfox3 is a well-known splicing regulator that is used as a marker for post-mitotic neurons in various vertebrate species. Although recent studies indicate a variable expression of Rbfox3 in non-neuronal tissues, including lung tissue, its cellular function in lung cancer remains largely unknown. Here, we report that the number of RBFOX3-positive cells in tumorous lung tissue is lower than that in normal lung tissue. As the transforming growth factor-? (TGF-?) signaling pathway is important in cancer progression, we investigated its role in RBFOX3 expression in A549 lung adenocarcinoma cells. TGF-?1 treatment inhibited RBFOX3 expression at the transcriptional level. Further, RBFOX3 depletion led to a change in the expression levels of a subset of proteins related to epithelial-mesenchymal transition (EMT), such as E-cadherin and Claudin-1, during TGF-?1-induced EMT. In immunofluorescence microscopic analysis, mesenchymal morphology was more prominent in RBFOX3-depleted cells than in control cells. These findings show that TGF-?-induced RBFOX3 inhibition plays an important role in EMT and propose a novel role for RBFOX3 in cancer progression. |*Epithelial-Mesenchymal Transition/genetics [MESH] |Adenocarcinoma of Lung [MESH] |Adenocarcinoma/genetics/*metabolism [MESH] |Antigens, Nuclear/genetics/*metabolism [MESH] |Cadherins/metabolism [MESH] |Carcinogenesis/genetics [MESH] |Cell Line, Tumor [MESH] |Claudin-1/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/genetics/*metabolism [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |RNA Splicing/genetics [MESH] |RNA, Small Interfering/genetics [MESH] |Respiratory Mucosa/*metabolism/pathology [MESH] |Signal Transduction [MESH]Transforming Growth Factor-?-Induced RBFOX3 Inhibition Promotes Epit(epmc).pdf DeepDyve Pubget Overpricing