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10.1038/ncomms12422 http://scihub22266oqcxt.onion/10.1038/ncomms12422 C4990645!4990645!27516371     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27516371&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27516371|t=2016. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells |pdf=|usr=}}{{27516371}} gab.com Text Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27516371 #FOAvip Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial?mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFR? and PDGFR?. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, ?-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions. Twit Text FOAVip Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27516371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27516371 #FOAvip English Wikipedia <ref>{{Cite pmid|27516371}}</ref> Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells #MMPMID27516371 Chen Q; Zhang H; Liu Y; Adams S; Eilken H; Stehling M; Corada M; Dejana E; Zhou B; Adams RH Nat Commun 2016[]; 7 (ä): ä PMID27516371show ga Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial?mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFR? and PDGFR?. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, ?-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions. äEndothelial cells are progenitors of cardiac pericytes and vascular sm(epmc).pdf DeepDyve Pubget Overpricing