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10.1038/ncomms12157 http://scihub22266oqcxt.onion/10.1038/ncomms12157 C4990632!4990632 !27515585     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27515585 &cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |pdf=|usr=}}{{27515585 }} gab.com Text Analysis of cancer genomes reveals basic features of human aging and its role in cancer development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27515585 #FOAvip Somatic mutations have long been implicated in aging and disease, but their impact on fitness and function is difficult to assess. Here by analysing human cancer genomes we identify mutational patterns associated with aging. Our analyses suggest that age-associated mutation load and burden double approximately every 8 years, similar to the all-cause mortality doubling time. This analysis further reveals variance in the rate of aging among different human tissues, for example, slightly accelerated aging of the reproductive system. Age-adjusted mutation load and burden correlate with the corresponding cancer incidence and precede it on average by 15 years, pointing to pre-clinical cancer development times. Behaviour of mutation load also exhibits gender differences and late-life reversals, explaining some gender-specific and late-life patterns in cancer incidence rates. Overall, this study characterizes some features of human aging and offers a mechanism for age being a risk factor for the onset of cancer. Twit Text FOAVip Analysis of cancer genomes reveals basic features of human aging and its role in cancer development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27515585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27515585 #FOAvip English Wikipedia <ref>{{Cite pmid|27515585 }}</ref> Analysis of cancer genomes reveals basic features of human aging and its role in cancer development #MMPMID27515585 Podolskiy DI ; Lobanov AV ; Kryukov GV ; Gladyshev VN Nat Commun 2016[Aug]; 7 (ä): 12157 PMID27515585 show ga Somatic mutations have long been implicated in aging and disease, but their impact on fitness and function is difficult to assess. Here by analysing human cancer genomes we identify mutational patterns associated with aging. Our analyses suggest that age-associated mutation load and burden double approximately every 8 years, similar to the all-cause mortality doubling time. This analysis further reveals variance in the rate of aging among different human tissues, for example, slightly accelerated aging of the reproductive system. Age-adjusted mutation load and burden correlate with the corresponding cancer incidence and precede it on average by 15 years, pointing to pre-clinical cancer development times. Behaviour of mutation load also exhibits gender differences and late-life reversals, explaining some gender-specific and late-life patterns in cancer incidence rates. Overall, this study characterizes some features of human aging and offers a mechanism for age being a risk factor for the onset of cancer. |Adolescent [MESH] |Adult [MESH] |Age Factors [MESH] |Aged [MESH] |Aging/*genetics [MESH] |Carcinogenesis/*genetics [MESH] |DNA Mutational Analysis/methods [MESH] |Exome Sequencing/methods [MESH] |Female [MESH] |Genome, Human/*genetics [MESH] |Humans [MESH] |Incidence [MESH] |Male [MESH] |Middle Aged [MESH] |Mutation [MESH] |Neoplasms/epidemiology/*genetics [MESH] |Risk Factors [MESH] |Sex Factors [MESH]Analysis of cancer genomes reveals basic features of human aging and i(epmc).pdf DeepDyve Pubget Overpricing